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磷脂酶C-β相关信号在恶性肿瘤增殖、转移及血管生成中的作用及相应的防护措施。

The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures.

作者信息

Wu Yu-Nuo, Su Xing, Wang Xue-Qin, Liu Na-Na, Xu Zhou-Wei

机构信息

Department of Clinical Medical, the First Clinical Medical College of Anhui Medical University, Hefei, Anhui, China.

Department of Emergency Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

出版信息

Front Oncol. 2023 Jul 28;13:1231875. doi: 10.3389/fonc.2023.1231875. eCollection 2023.

DOI:10.3389/fonc.2023.1231875
PMID:37576896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10419273/
Abstract

PLC-β is widely distributed in eukaryotic cells and is the key enzyme in phosphatidylinositol signal transduction pathway. The cellular functions regulated by its four subtypes (PLC-β1, PLC-β2, PLC-β3, PLC-β4) play an important role in maintaining homeostasis of organism. PLC-β and its related signals can promote or inhibit the occurrence and development of cancer by affecting the growth, differentiation and metastasis of cells, while targeted intervention of PLC-β1-PI3K-AKT, PLC-β2/CD133, CXCR2-NHERF1-PLC-β3, Gαq-PLC-β4-PKC-MAPK and so on can provide new strategies for the precise prevention and treatment of malignant tumors. This paper reviews the mechanism of PLC-β in various tumor cells from four aspects: proliferation and differentiation, invasion and metastasis, angiogenesis and protective measures.

摘要

磷脂酶C-β（PLC-β）广泛分布于真核细胞中，是磷脂酰肌醇信号转导途径中的关键酶。其四种亚型（PLC-β1、PLC-β2、PLC-β3、PLC-β4）所调节的细胞功能在维持机体稳态中发挥着重要作用。PLC-β及其相关信号可通过影响细胞的生长、分化和转移来促进或抑制癌症的发生和发展，而对PLC-β1-PI3K-AKT、PLC-β2/CD133、CXCR2-NHERF1-PLC-β3、Gαq-PLC-β4-PKC-MAPK等进行靶向干预可为恶性肿瘤的精准防治提供新策略。本文从增殖与分化、侵袭与转移、血管生成及保护措施四个方面综述了PLC-β在各种肿瘤细胞中的作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/24e711c14dd0/fonc-13-1231875-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/345bb77bdb3f/fonc-13-1231875-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/b16c5c44caa6/fonc-13-1231875-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/acc5bb091541/fonc-13-1231875-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/039ffb196a11/fonc-13-1231875-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/24e711c14dd0/fonc-13-1231875-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/345bb77bdb3f/fonc-13-1231875-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/b16c5c44caa6/fonc-13-1231875-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/acc5bb091541/fonc-13-1231875-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/039ffb196a11/fonc-13-1231875-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/481a/10419273/24e711c14dd0/fonc-13-1231875-g005.jpg

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