Bao Siqi, Sun Shuanghui, Li Lin, Xu Lei
School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, China.
Front Bioeng Biotechnol. 2023 Jul 27;11:1221458. doi: 10.3389/fbioe.2023.1221458. eCollection 2023.
In recent years, massive bacterial infections have led to human illness and death, reminding us of the urgent need to develop effective and long-lasting antimicrobial materials. In this paper, Ag-TiO/ZIF-8 with good environmental friendliness and biological antibacterial activity was prepared by solvothermal method. The structure and morphology of the synthesized materials were characterized by XRD, FT-IR, SEM-EDS, TEM, XPS, and BET. To investigate the antibacterial activity of the synthesized samples, and were used as target bacteria for experimental studies of zone of inhibition, bacterial growth curves, minimum bactericidal concentration and antibacterial durability. The results demonstrated that 20 wt.%Ag-TiO/ZIF-8 had the best bacteriostatic effect on and under dark and UV conditions compared to TiO and ZIF-8. Under the same conditions, the diameter of the inhibition circle of 20 wt% Ag-TiO/ZIF-8 is 8.5-11.5 mm larger than that of its constituent material 4 wt% Ag-TiO, with more obvious antibacterial effect and better antibacterial performance. It is also proposed that the excellent antibacterial activity of Ag-TiO/ZIF-8 is due to the synergistic effect of Ag-TiO and ZIF-8 under UV light. In addition, the prepared material has good stability and durability with effective antimicrobial activity for more than 5 months.
近年来，大规模的细菌感染已导致人类患病和死亡，这提醒我们迫切需要开发有效且持久的抗菌材料。本文采用溶剂热法制备了具有良好环境友好性和生物抗菌活性的Ag-TiO/ZIF-8。通过XRD、FT-IR、SEM-EDS、TEM、XPS和BET对合成材料的结构和形貌进行了表征。为了研究合成样品的抗菌活性，以[具体细菌1]和[具体细菌2]作为目标细菌进行抑菌圈、细菌生长曲线、最低杀菌浓度和抗菌耐久性的实验研究。结果表明，与TiO和ZIF-8相比，20 wt.%Ag-TiO/ZIF-8在黑暗和紫外条件下对[具体细菌1]和[具体细菌2]具有最佳抑菌效果。在相同条件下，20 wt% Ag-TiO/ZIF-8的抑菌圈直径比其组成材料4 wt% Ag-TiO的抑菌圈直径大8.5 - 11.5 mm，抗菌效果更明显，抗菌性能更好。还提出Ag-TiO/ZIF-8优异的抗菌活性归因于紫外光下Ag-TiO和ZIF-8的协同作用。此外，制备的材料具有良好的稳定性和耐久性，有效抗菌活性超过5个月。
