聚多巴胺功能化硒纳米粒子作为一种高效的光响应抗菌平台。

Polydopamine-functionalized selenium nanoparticles as an efficient photoresponsive antibacterial platform.

作者信息

Sun Meng, Gao Ping, Wang Bao, Li Xiangyang, Shao Donghan, Xu Yan, Li Leijiao, Li Yunhui, Zhu Jianwei, Li Wenliang, Xue Yingxue

机构信息

School of Chemistry and Environmental Engineering, Changchun University of Science and Technology Changchun 130022 China

Zhongshan Institute of Changchun University of Science and Technology Zhongshan 528437 China.

出版信息

RSC Adv. 2023 Mar 29;13(15):9998-10004. doi: 10.1039/d2ra07737j. eCollection 2023 Mar 27.

A photoresponsive therapeutic antibacterial platform was designed and constructed using polydopamine-functionalized selenium nanoparticles as a carrier loaded with indocyanine green (Se@PDA-ICG). The therapeutic platform was confirmed by characterization and the antibacterial activity of Se@PDA-ICG against () and () was investigated. Under 808 nm laser irradiation, the antibacterial rate of Se@PDA-ICG against and was 100% at 125 μg mL. Furthermore, in a mouse wound infection model, the wound closure rate of the Se@PDA-ICG photoresponse group was 88.74% compared with 45.8% for the control group after 8 days of treatment, indicating that it could effectively kill bacteria and dramatically accelerate the wound healing process. These results suggested that Se@PDA-ICG could be a promising photo-activated antibacterial candidate material for biomedical applications.

以聚多巴胺功能化的硒纳米粒子为载体负载吲哚菁绿（Se@PDA-ICG），设计并构建了一种光响应性治疗性抗菌平台。通过表征确认了该治疗平台，并研究了Se@PDA-ICG对（此处原文缺失具体菌种信息）和（此处原文缺失具体菌种信息）的抗菌活性。在808 nm激光照射下，Se@PDA-ICG在125 μg/mL时对（此处原文缺失具体菌种信息）和（此处原文缺失具体菌种信息）的抗菌率为100%。此外，在小鼠伤口感染模型中，治疗8天后，Se@PDA-ICG光响应组的伤口愈合率为88.74%，而对照组为45.8%，表明它可以有效杀灭细菌并显著加速伤口愈合过程。这些结果表明，Se@PDA-ICG可能是一种有前途的用于生物医学应用的光激活抗菌候选材料。