新冠疫苗接种后继发噬血细胞性淋巴组织细胞增生症所致急性肝衰竭——病例报告及文献综述
Acute Liver Failure Caused by Secondary Hemophagocytic Lymphohistiocytosis After COVID-19 Vaccination - Case Report and Literature Review.
作者信息
Premec Hrvoje, Živko Matea, Mijić Maja, Jelić-Puškarić Biljana, Lalovac Miloš, Filipec Kanižaj Tajana, Sobočan Nikola
机构信息
Department of Gastroenterology, University Hospital Merkur, Zagreb, Croatia.
School of Medicine, University of Zagreb, Zagreb, Croatia.
出版信息
Int Med Case Rep J. 2023 Aug 7;16:449-455. doi: 10.2147/IMCRJ.S417347. eCollection 2023.
Hemophagocytic lymphohistiocytosis (HLH) is a congenital or acquired hyperinflammatory syndrome, in some cases accompanied by acute liver failure. We present a case report of acute liver failure associated with HLH after COVID-19 vaccination and bring a literature review of the connection between HLH and COVID-19 vaccination. HLH has significant mortality rate, and liver transplantation is not a therapeutic option. Therefore, early recognition and timely conservative treatment are corner stones in reducing HLH-related morbidity and mortality.
噬血细胞性淋巴组织细胞增生症（HLH）是一种先天性或获得性高炎症综合征，在某些情况下伴有急性肝衰竭。我们报告一例新冠病毒疫苗接种后与HLH相关的急性肝衰竭病例，并对HLH与新冠病毒疫苗接种之间的关联进行文献综述。HLH的死亡率很高，肝移植并非治疗选择。因此，早期识别和及时的保守治疗是降低HLH相关发病率和死亡率的基石。
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