阿根廷婴幼儿百日咳疫苗接种情况：家长报告的五价全细胞或六价无细胞百日咳疫苗接种后的反应原性、对日常生活的影响及满意度。
Infant vaccination against pertussis in Argentina: Parent-reported outcomes on reactogenicity, impact on daily routine and satisfaction after pentavalent whole-cell or hexavalent acellular pertussis vaccines.
作者信息
Gentile Angela, Castellano Vanesa Edelvais, Pacchiotti Anabella, Del Pino Mariela, Bollón Lucía Romero, Lieste Micaela, Deluca Mercedes, Vargas-Zambrano Juan C
机构信息
Epidemiology, Ricardo Gutierrez Children's Hospital, Gallo 1330, Buenos Aires City, Argentina.
Stamboulian Vaccines Services, French 3085, Buenos Aires City, Argentina.
出版信息
Vaccine X. 2023 Jun 28;14:100339. doi: 10.1016/j.jvacx.2023.100339. eCollection 2023 Aug.
INTRODUCTION
In Argentina, a pentavalent whole-cell pertussis vaccine (wP) is used in the National Immunization Program, however hexavalent acellular pertussis (aP) vaccines are available in the private market.
OBJECTIVE
To describe parent or guardianś perceptions on reactogenicity, daily routine and satisfaction after a first or third dose of a wP-pentavalent plus IPV (wP-group) or the fully-liquid aP-hexavalent vaccine (aP-group) in infants.
MATERIAL AND METHODS
This was a prospective observational and analytical study. Parents or guardians of infants born at term attending a public or private vaccination center in Buenos Aires City were invited to participate. All parents or guardians had completed 12-year schooling and were asked to fill out an online 7-day post vaccination questionnaire. The questionnaire was validated as the first phase of the study. Descriptive analysis of study variables was carried out, REDCap was used for the online survey, and STATA 14 for data analysis.
RESULTS
1071 parents or guardians answered the questionnaire (response rate 82%), 530 for wP-group and 541 for aP-group.Local and systemic adverse reactions, in groups wP and aP respectively, were: pain 83%, 28%; swelling 63%, 16%; redness 52%, 22%; irritability 72%, 52%; fever 37%, 8%; loss of appetite 36%, 19%; drowsiness 38%, 27%; and vomiting 15%, 11%.Impact on daily life: social activities 36%, 20%; routine 48%, 24%; mood 39%, 23%; vitality 47%, 24%; sleep 50%, 30%; and appetite 22%, 7%.Parents were satisfied with the vaccination process in 96% and 98% for wP-group and aP-group respectively. Parents reported willingness to bring infant for future vaccine doses in 97% and 99% for wP-group and aP-group respectively.
CONCLUSIONS
Reported reactogenicity and impact on family daily routine was higher in infants receiving wP-pentavalent than aP-hexavalent vaccines. Parents in both groups conveyed vaccine acceptance and positive intentions for future immunizations.
引言
在阿根廷，国家免疫规划中使用的是五价全细胞百日咳疫苗（wP），不过私立市场上有六价无细胞百日咳（aP）疫苗。
目的
描述婴儿接种第一剂或第三剂五价wP联合脊髓灰质炎灭活疫苗（wP组）或全液体六价aP疫苗（aP组）后，父母或监护人对反应原性、日常生活及满意度的看法。
材料与方法
这是一项前瞻性观察分析研究。邀请了在布宜诺斯艾利斯市公立或私立疫苗接种中心接种的足月出生婴儿的父母或监护人参与。所有父母或监护人都完成了12年学业，并被要求填写一份接种疫苗7天后的在线问卷。该问卷作为研究的第一阶段进行了验证。对研究变量进行描述性分析，使用REDCap进行在线调查，使用STATA 14进行数据分析。
结果
1071名父母或监护人回答了问卷（回复率82%），wP组530人，aP组541人。wP组和aP组的局部和全身不良反应分别为：疼痛83%、28%；肿胀63%、16%；发红52%、22%；易激惹72%、52%；发热37%、8%；食欲不振36%、19%；嗜睡38%、27%；呕吐15%、11%。对日常生活的影响：社交活动36%、20%；日常活动48%、24%；情绪39%、23%；活力47%、24%；睡眠50%、30%；食欲22%、7%。wP组和aP组父母对疫苗接种过程的满意度分别为96%和98%。wP组和aP组父母分别有97%和99%表示愿意带婴儿接种后续疫苗。
结论
接种五价wP疫苗的婴儿报告的反应原性及对家庭日常生活的影响高于六价aP疫苗。两组父母都表示接受疫苗，并对未来的免疫接种有积极意愿。
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