Li M X, Jiang Y Z, Ji C, Li G Y, Tian G Z, Guo S P
Zhonghua Zhong Liu Za Zhi. 1986 Jul;8(4):245-6.
Forestomach papilloma and carcinoma, as well as liver lesion, were induced in mice by gavaging precursors of the new nitrosamine, MAMBNA (N-3-methylbutyl-N-1-methylacetonylnitrosamine) and NaNO2. The results were-similar to those in mice and rats fed on preformed MAMBNA compound. However, the induction of such tumors by in vivo formation of MAMBNA required longer time and much larger doses. Moreover, the lesions of epithelial hyperplasia in the urinary bladder, lymphoid tumor, intestinal carcinoma and interstitial-cell tumor of the testis also developed in some of the experimental animals. This may indicate that the intragastric synthesis of MAMBNA is less effective in the production of forestomach tumors in mice.
通过向小鼠灌喂新型亚硝胺MAMBNA（N-3-甲基丁基-N-1-甲基丙酮基亚硝胺）和亚硝酸钠的前体，诱发了小鼠前胃乳头瘤和癌以及肝脏病变。结果与喂食预制MAMBNA化合物的小鼠和大鼠的结果相似。然而，通过体内形成MAMBNA诱导此类肿瘤需要更长时间和更大剂量。此外，一些实验动物还出现了膀胱上皮增生病变、淋巴瘤、肠癌和睾丸间质细胞瘤。这可能表明胃内合成MAMBNA在小鼠前胃肿瘤的产生中效果较差。
