McDonough Catherine, Li Yan Chak, Vangeepuram Nita, Liu Bian, Pandey Gaurav
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
medRxiv. 2023 Aug 4:2023.08.02.23293517. doi: 10.1101/2023.08.02.23293517.
The prevalence of type 2 diabetes mellitus (DM) and prediabetes (preDM) is rapidly increasing among youth, posing significant health and economic consequences. To address this growing concern, we created the most comprehensive youth-focused diabetes dataset to date derived from National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018. The dataset, consisting of 15,149 youth aged 12 to 19 years, encompasses preDM/DM relevant variables from sociodemographic, health status, diet, and other lifestyle behavior domains. An interactive web portal, POND (Prediabetes/diabetes in youth ONline Dashboard), was developed to provide public access to the dataset, allowing users to explore variables potentially associated with youth preDM/DM. Leveraging statistical and machine learning methods, we conducted two case studies, revealing established and lesser-known variables linked to youth preDM/DM. This dataset and portal can facilitate future studies to inform prevention and management strategies for youth prediabetes and diabetes.
2型糖尿病(DM)和糖尿病前期(preDM)在青少年中的患病率正在迅速上升,带来了重大的健康和经济后果。为了应对这一日益严重的问题,我们创建了迄今为止最全面的以青少年为重点的糖尿病数据集,该数据集源自1999年至2018年的美国国家健康与营养检查调查(NHANES)数据。该数据集包含15149名年龄在12至19岁之间的青少年,涵盖了社会人口统计学、健康状况、饮食和其他生活方式行为领域中与糖尿病前期/糖尿病相关的变量。我们开发了一个交互式网络门户POND(青少年糖尿病前期/糖尿病在线仪表板),以便公众能够访问该数据集,让用户探索可能与青少年糖尿病前期/糖尿病相关的变量。利用统计和机器学习方法,我们进行了两个案例研究,揭示了与青少年糖尿病前期/糖尿病相关的已知和鲜为人知的变量。该数据集和门户可以促进未来的研究,为青少年糖尿病前期和糖尿病的预防和管理策略提供信息。