青霉震颤素A引起的小鼠长时间震颤的影响。

Effects of prolonged tremor due to penitrem A in mice.

作者信息

Jortner B S, Ehrich M, Katherman A E, Huckle W R, Carter M E

出版信息

Drug Chem Toxicol. 1986;9(2):101-16. doi: 10.3109/01480548608998269.

Abstract

Adult mice were given subcutaneous injections of purified penitrem A (10 mg/kg) dissolved in corn oil. The mycotoxin was prepared by ether extraction and absorption chromatography; identity was established by absorption and mass spectra. Tremors were sustained for 72 hr following a single dose; readministration every 3 days was used to provide continuous trembling for 18 days. No lesions specifically attributed to penitrem A could be detected by histological examination of brains even after 18 days of trembling. Pharmacological agents affecting central nervous system neurotransmitters had some capacity to modify the effects of penitrem A. The results of those studies were such that a definitive conclusion regarding mechanisms of action of the toxin could not be determined.

摘要

给成年小鼠皮下注射溶解于玉米油中的纯化青霉震颤素A（10毫克/千克）。该霉菌毒素通过乙醚萃取和吸附色谱法制备；通过吸收光谱和质谱确定其特性。单次给药后震颤持续72小时；每3天重新给药一次，以提供持续18天的颤抖。即使在颤抖18天后，通过对大脑进行组织学检查，也未发现明确归因于青霉震颤素A的损伤。影响中枢神经系统神经递质的药物有一定能力改变青霉震颤素A的作用效果。这些研究结果表明，无法确定该毒素作用机制的确切结论。