来自 crustosum 青霉的新型代谢产物，包括震颤性霉菌毒素青霉震颤素E。
Novel metabolites from Penicillium crustosum, including penitrem E, a tremorgenic mycotoxin.
作者信息
Kyriakidis N, Waight E S, Day J B, Mantle P G
出版信息
Appl Environ Microbiol. 1981 Jul;42(1):61-2. doi: 10.1128/aem.42.1.61-62.1981.
Abstract
Two new indolic metabolites were isolated from Penicillium crustosum and separated from other penitrem mycotoxins by high-performance liquid chromatography. Penitrem D is a deoxy-penitrem A. Penitrem E is dechloro-penitrem A and was shown to be tremorgenic in mice, although it has only one-third of the activity of penitrem A. Roquefortine was also shown, for the first time, to be an important metabolic product of P. crustosum.
摘要
从 crustosum 青霉中分离出两种新的吲哚类代谢产物，并通过高效液相色谱法将其与其他青霉震颤素霉菌毒素分离。青霉震颤素 D 是脱氧青霉震颤素 A。青霉震颤素 E 是脱氯青霉震颤素 A，尽管其活性仅为青霉震颤素 A 的三分之一，但在小鼠中显示出致震颤性。首次证明，展青霉素也是 crustosum 青霉的重要代谢产物。
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