Hood R D
Drug Chem Toxicol. 1986;9(2):185-90. doi: 10.3109/01480548608998274.
T-2 toxin and rubratoxin B are toxic mold metabolites that are known mammalian teratogens. These mycotoxins were given individually or together by ip injection to pregnant CD-1 mice at doses of 0.5 (T-2 toxin) and 0.4 (rubratoxin B) mg/kg on day 10 of gestation. The combination resulted in an increased adverse effect on both fetal weight and mortality of the conceptus in comparison with either treatment given alone at the doses used. Only T-2 toxin resulted in gross malformations, and these were not increased in incidence by addition of rubratoxin B.
T-2毒素和红天精B是有毒的霉菌代谢产物，已知是哺乳动物致畸剂。在妊娠第10天，将这些霉菌毒素以0.5毫克/千克（T-2毒素）和0.4毫克/千克（红天精B）的剂量通过腹腔注射单独或联合给予怀孕的CD-1小鼠。与单独使用相同剂量的任何一种处理相比，联合使用对胎儿体重和胚胎死亡率产生了更大的不良影响。只有T-2毒素导致明显的畸形，并且添加红天精B并未增加畸形的发生率。
