N.P. Bechtereva Institute of the Human Brain of Russian Academy of Sciences, Saint-Petersburg, Russia.
Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
Psychophysiology. 2023 Dec;60(12):e14403. doi: 10.1111/psyp.14403. Epub 2023 Aug 14.
Symptoms in patients with obsessive-compulsive disorder (OCD) are associated with impairment in cognitive control, attention, and action inhibition. We investigated OCD group differences relative to healthy subjects in terms of event-related alpha and beta range synchronization (ERS) and desynchronization (ERD) during a visually cued Go/NoGo task. Subjects were 62 OCD patients and 296 healthy controls (HC). The OCD group in comparison with HC, showed a changed value of alpha/beta oscillatory power over the central cortex, in particular, an increase in the alpha/beta ERD over the central-parietal cortex during the interstimulus interval (Cue condition) as well as changes in the postmovement beta synchronization topography and frequency. Over the frontal cortex, the OCD group showed an increase in magnitude of the beta ERS in NoGo condition. Within the parietal-occipital ERS/ERD modulations, the OCD group showed an increase in the alpha/beta ERD over the parietal cortex after the presentation of the visual stimuli as well as a decrease in the beta ERD over the occipital cortex after the presentation of the Cue and Go stimuli. The specific properties in the ERS/ERD patterns observed in the OCD group may reflect high involvement of the frontal and central cortex in action preparation and action inhibition processes and, possibly, in maintaining the motor program, which might be a result of the dysfunction of the cortico-striato-thalamo-cortical circuits involving prefrontal cortex. The data about enhanced involvement of the parietal cortex in the evaluation of the visual stimuli are in line with the assumption about overfocused attention in OCD.
强迫症（OCD）患者的症状与认知控制、注意力和动作抑制受损有关。我们在视觉线索 Go/NoGo 任务中研究了 OCD 组相对于健康对照组（HC）在事件相关 alpha 和 beta 范围同步（ERS）和去同步（ERD）方面的差异。研究对象包括 62 名 OCD 患者和 296 名健康对照组（HC）。与 HC 相比，OCD 组在中央皮质的 alpha/beta 振荡功率值上表现出变化，特别是在刺激间间隔期间中央顶叶皮质的 alpha/beta ERD 增加，以及在运动后 beta 同步拓扑和频率上的变化。在前额叶皮质上，OCD 组在 NoGo 条件下表现出 beta ERS 幅度的增加。在顶枕叶 ERS/ERD 调制中，OCD 组在视觉刺激呈现后表现出顶叶皮质上的 alpha/beta ERD 增加，以及在 Cue 和 Go 刺激呈现后枕叶皮质上的 beta ERD 减少。在 OCD 组中观察到的 ERS/ERD 模式的特定性质可能反映了前额叶和中央皮质在动作准备和动作抑制过程中以及可能在维持运动程序中的高度参与，这可能是涉及前额叶皮质的皮质纹状体丘脑皮质回路功能障碍的结果。关于顶叶皮质在视觉刺激评估中参与度增加的数据与 OCD 中过度关注注意力的假设一致。
