Fujimoto Toshiro, Okumura Eiichi, Takeuchi Kouzou, Kodabashi Atsushi, Tanaka Hiroaki, Otsubo Toshiaki, Nakamura Katsumi, Sekine Masaki, Kamiya Shinichiro, Higashi Yuji, Tsuji Miwa, Shimooki Susumu, Tamura Toshiyo
Fujimoto Hayasuzu Hospital, Yokakai Association, Miyazaki, Japan.
Open Neuroimag J. 2012;6:26-36. doi: 10.2174/1874440001206010026. Epub 2012 Jun 1.
We studied differences in the spatiotemporal dynamics of cortical oscillation across brain regions of patients with schizophrenia and normal subjects during the auditory oddball task using magnetoencephalography (MEG) and electroencephalography (EEG).
Ten right-handed male schizophrenia patients were studied. We used a newly developed adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction of MEG and EEG data, and obtained consecutive images in functional maps of event-related desynchronization (ERD) and synchronization (ERS) in theta, lower alpha (8-10 Hz), upper alpha (10-13 Hz), and beta bands.
Beta ERD power at 750-1000 ms in patients was significantly increased in large right upper temporal and parietal regions and small upper portions of bilateral dorsal frontal and dorsal-medial parietal regions. Theta ERS power in schizophrenic patients during the oddball task was significantly increased in the left temporal pole at 250-500 ms, and was significantly increased in dorsal, medial frontal, and anterior portions of the anterior cingulate cortex in both hemispheres, and the left portion of lateral temporal regions at 500-750 ms, compared to the control group (family-wise error correction p<0.05). Lower alpha ERS power was significantly decreased in the right occipital region at 500-750 ms and in the right midline parietal and bilateral occipital regions at 750-1000 ms. Upper alpha ERS power was significantly decreased in right midline parietal and left occipital regions at 750-1000 ms.
ERD/ERS changes were noted in the left temporal pole and midline frontal and anterior cingulate cortex in theta ERS, occipital lobe in alpha ERS, and right temporal-frontal-parietal, midline frontal, and anterior cingulate cortex in beta ERD. These findings may reflect disturbances in interaction among active large neuronal groups and their communication with each other that may be related to abnormal cognitive and psychopathological function.
Study of ERD and ERS by time-frequency analyses using MEG is useful to clarify data processing dysfunction in schizophrenia.
我们使用脑磁图（MEG）和脑电图（EEG）研究了精神分裂症患者与正常受试者在听觉Oddball任务期间大脑各区域皮质振荡的时空动态差异。
对10名右利手男性精神分裂症患者进行了研究。我们使用了一种新开发的自适应空间滤波算法，该算法针对MEG和EEG数据的稳健源时频重建进行了优化，并在事件相关去同步化（ERD）和同步化（ERS）的功能图中，获得了θ波、低α波（8 - 10赫兹）、高α波（10 - 13赫兹）和β波段的连续图像。
患者在750 - 1000毫秒时，右侧颞叶上部和顶叶的大片区域以及双侧背侧额叶和背内侧顶叶的小上部区域的β波ERD功率显著增加。与对照组相比，精神分裂症患者在Oddball任务期间，左侧颞极在250 - 500毫秒时的θ波ERS功率显著增加，在两个半球的背侧、内侧额叶和前扣带回皮质的前部以及左侧颞叶外侧区域在500 - 750毫秒时的θ波ERS功率也显著增加（家族性错误校正p<0.05）。低α波ERS功率在500 - 750毫秒时右侧枕叶区域以及在750 - 1000毫秒时右侧中线顶叶和双侧枕叶区域显著降低。高α波ERS功率在750 - 1000毫秒时右侧中线顶叶和左侧枕叶区域显著降低。
在θ波ERS中，左侧颞极、中线额叶和前扣带回皮质出现ERD/ERS变化；在α波ERS中，枕叶出现变化；在β波ERD中，右侧颞 - 额 - 顶叶、中线额叶和前扣带回皮质出现变化。这些发现可能反映了活跃的大神经元群体之间相互作用及其相互通信的紊乱，这可能与异常的认知和精神病理功能有关。
使用MEG进行时频分析研究ERD和ERS有助于阐明精神分裂症中的数据处理功能障碍。
