Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, CDMX, Av. Wilfrido Massieu Esq. Cda. Miguel Stampa S/N, Delegación Gustavo A. Madero, C.P. 07738, Coahuila, México.
Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Delegación Gustavo A. Madero, CDMX, Av. Acueducto. La Laguna Ticomán, C.P. 07340, Coahuila, México.
Plant Foods Hum Nutr. 2023 Sep;78(3):493-505. doi: 10.1007/s11130-023-01085-3. Epub 2023 Aug 14.
Hypertension is a condition induced by oxidative stress causing an alteration in the endothelium, which increases the risk of suffering from other degenerative diseases. This review compiles the findings on peptides from food proteins with antioxidant and antihypertensive activities. Antihypertensive peptides are mainly focused on renin inhibition. Peptides containing hydrophobic amino acids have antioxidant and renin inhibitory activities, as reported by studies on the biological activity of peptides from various food sources evaluated separately and simultaneously. Peptides from food sources can present multiple biological activities. Moreover, antioxidant peptides have the potential to be evaluated against renin, offering an alternative for hypertension therapy without causing adverse side effects.
高血压是一种由氧化应激引起的疾病，会导致内皮细胞发生改变，从而增加患其他退行性疾病的风险。本综述总结了具有抗氧化和降压活性的食物蛋白肽的研究结果。降压肽主要集中在抑制肾素上。含有疏水性氨基酸的肽具有抗氧化和肾素抑制活性，这是从各种食物来源的肽的生物活性研究中分别和同时报道的。食物来源的肽可以具有多种生物活性。此外，抗氧化肽有可能针对肾素来进行评估，为高血压治疗提供一种替代方法，而不会产生不良反应。
