Osinskiĭ S P, Gusev A N
Eksp Onkol. 1986;8(4):62-3.
It is shown that the antitumour effect of local hyperthermia (2450 MHz, 43 degrees C, 60 min) is enhanced essentially if it follows immediately after i. v. infusion of 20% glucose solution at a rate of 80 mg X kg-1 X min-1 for 90 min in experiments on rats bearing the Guerin carcinoma. Under such a combined treatment the rate of tumour growth decreases by a factor of 2. An assumption is advanced that such an enhancement of the hyperthermia effect is caused mainly by low pH values of the tumour which are observed under hyperglycemia.
结果表明，在荷Guerin癌大鼠实验中，若在静脉输注20%葡萄糖溶液（速率为80mg·kg⁻¹·min⁻¹，持续90分钟）后立即进行局部热疗（2450MHz，43℃，60分钟），局部热疗的抗肿瘤效果会显著增强。在这种联合治疗下，肿瘤生长速率降低了一半。有人提出假设，热疗效果的这种增强主要是由高血糖状态下肿瘤的低pH值引起的。
