Department of Mechanical Engineering, Gonzaga University, Spokane, Washington, United States of America.
Department of Mechanical Engineering, Brigham Young University, Provo, Utah, United States of America.
PLoS One. 2023 Aug 14;18(8):e0288941. doi: 10.1371/journal.pone.0288941. eCollection 2023.
Pectus carinatum is a chest wall deformity that is often treated through the wearing of an external brace. The treatment of the deformity could benefit from a greater understanding of chest wall characteristics under prolonged loading. These characteristics are difficult to model directly but empirical studies can be used to create statistical models. 185 patients from 2018-2020 received bracing treatment. Data on the severity of the deformity, treatment pressures, and time of wear were recorded at the first fitting and all subsequent follow-up visits. This data was analyzed using a statistical mixed effects model to identify significant measures and trends in treatment. These models were designed to help quantify changes in chest wall characteristics through prolonged bracing. Two statistical models were created. The first model predicts the change in the amount of pressure to correct the deformity after bracing for a given time and pressure. The second model predicts the change in pressure response by the body on the brace after bracing for a given time and pressure. These models show a high significance in the amount of pressure and time to the changes in the chest wall response. Initial deformity severity is also significant in changes to the deformity. The statistical models predict general trends in pectus carinatum brace treatment and can assist in creating treatment plans, motivating patient compliance, and can inform the design of future treatment systems.
鸡胸是一种胸廓畸形，通常通过佩戴外部支架进行治疗。为了更好地了解胸廓在长时间受力下的特征，有助于改进畸形的治疗方法。这些特征难以直接建模，但可通过实证研究创建统计模型。2018 年至 2020 年期间，185 名患者接受了支架治疗。在首次适配和所有后续随访就诊时，记录了畸形严重程度、治疗压力和佩戴时间的数据。使用统计混合效应模型分析这些数据，以确定治疗过程中的显著措施和趋势。这些模型旨在帮助通过长时间的支架治疗来量化胸廓特征的变化。创建了两个统计模型。第一个模型预测了在给定时间和压力下，矫正畸形所需的压力变化量。第二个模型预测了在给定时间和压力下，身体对支架的压力反应变化。这些模型表明，压力量和胸廓反应变化时间与压力变化之间具有高度显著性。初始畸形严重程度也与畸形变化显著相关。统计模型预测了鸡胸支架治疗的一般趋势，有助于制定治疗计划、激励患者依从性，并为未来的治疗系统设计提供信息。
