Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan 570311, China.
Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Mol Pharm. 2023 Sep 4;20(9):4743-4757. doi: 10.1021/acs.molpharmaceut.3c00491. Epub 2023 Aug 14.
Currently, the low survival rate and poor prognosis of patients with nasopharyngeal carcinoma are ascribed to the lack of early and accurate diagnosis and resistance to radiotherapy. In parallel, the integration of imaging-guided diagnosis and precise treatment has gained much attention in the field of theranostic nanotechnology. However, constructing dual-modal imaging-guided nanotheranostics with desired imaging performance as well as great biocompatibility remains challenging. Therefore, we developed a simple but multifunctional nanotheranostic GdCPP for the early and accurate diagnosis and efficient treatment of nasopharyngeal carcinoma (NPC), which combined fluorescence imaging and magnetic resonance imaging (MRI) onto a single nanoplatform for imaging-guided subsequent photodynamic therapy (PDT). GdCPP had an appropriate particle size (81.93 ± 0.69 nm) and was highly stable, resulting in sufficient tumor accumulation, which along with massive reactive oxygen species (ROS) generation upon irradiation further significantly killed tumor cells. Moreover, GdCPP owned much stronger relaxivity (9.396 mM s) compared to clinically used Gd-DTPA (5.034 mM s) and exhibited better WI MRI performance. Under dual-modal imaging-guided PDT, GdCPP achieved efficient therapeutic outcomes without causing any noticeable tissue damage. The results of and studies indicated that GdCPP may be a suitable candidate for dual-modal imaging-guided precision tumor therapy.
目前，鼻咽癌患者的生存率低和预后差归因于缺乏早期和准确的诊断以及对放疗的耐药性。同时，影像引导诊断和精确治疗的整合在治疗性纳米技术领域受到了广泛关注。然而，构建具有所需成像性能和良好生物相容性的双模式影像引导纳米治疗仍然具有挑战性。因此，我们开发了一种简单但多功能的纳米治疗剂 GdCPP，用于早期和准确诊断以及高效治疗鼻咽癌（NPC），它将荧光成像和磁共振成像（MRI）结合到单个纳米平台上，用于影像引导随后的光动力治疗（PDT）。GdCPP 具有适当的粒径（81.93±0.69nm）和高度稳定性，导致足够的肿瘤积累，并且在照射下会产生大量的活性氧（ROS），从而进一步显著杀死肿瘤细胞。此外，GdCPP 的弛豫率（9.396mM s）比临床使用的 Gd-DTPA（5.034mM s）强得多，并且表现出更好的 WI MRI 性能。在双模式影像引导 PDT 下，GdCPP 实现了有效的治疗效果，而不会造成任何明显的组织损伤。[和]研究的结果表明，GdCPP 可能是双模式影像引导精确肿瘤治疗的合适候选者。
