Guangdong Provincial Engineering and Technology Center of Advanced and Portable Medical Devices, School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen 518107, China.
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.
Nanoscale. 2021 Oct 8;13(38):16197-16206. doi: 10.1039/d1nr04489c.
Nanotheranostics for fluorescence/magnetic resonance (FL/MR) dual-modal imaging guided photodynamic therapy (PDT) are highly desirable in precision and personalized medicine. In this study, a facile non-covalent electrostatic interaction induced self-assembly strategy is developed to effectively encapsulate gadolinium porphyrin (Gd-TCPP) into homogeneous supramolecular nanoparticles (referred to as Gd-PNPs). Gd-PNPs exhibit the following advantages: (1) excellent FL imaging property, high longitudinal relaxivity (16.157 mM s), and good singlet oxygen (O) production property; (2) excellent long-term colloidal stability, dispersity and biocompatibility; and (3) enhanced FL/MR imaging guided tumor growth inhibition efficiency for CT 26 tumor-bearing mice. This study provides a new strategy to design and synthesize metalloporphyrin-based nanotheranostics for imaging-guided cancer therapy with enhanced theranostic properties.
用于荧光/磁共振（FL/MR）双模式成像引导光动力治疗（PDT）的纳米诊疗剂在精准医学和个性化医疗中是非常需要的。在这项研究中，开发了一种简便的非共价静电相互作用诱导的自组装策略，以有效地将钆卟啉（Gd-TCPP）封装到均匀的超分子纳米颗粒中（称为 Gd-PNPs）。Gd-PNPs 具有以下优点：（1）优异的 FL 成像性能，高纵向弛豫率（16.157 mM s）和良好的单线态氧（O）生成性能；（2）优异的长期胶体稳定性、分散性和生物相容性；以及（3）增强 CT 26 荷瘤小鼠的 FL/MR 成像引导肿瘤生长抑制效率。本研究为设计和合成基于金属卟啉的纳米诊疗剂提供了一种新策略，用于具有增强治疗效果的成像引导癌症治疗。
