用于丙型肝炎病毒人体感染控制模型的挑战接种物。
Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model.
机构信息
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada.
出版信息
Clin Infect Dis. 2023 Aug 14;77(Suppl 3):S257-S261. doi: 10.1093/cid/ciad336.
Abstract
For any controlled human infection model (CHIM), a safe, standardized, and biologically relevant challenge inoculum is necessary. For hepatitis C virus (HCV) CHIM, we propose that human-derived high-titer inocula of several viral genotypes with extensive virologic, serologic, and molecular characterizations should be the most appropriate approach. These inocula should first be tested in human volunteers in a step-wise manner to ensure safety, reproducibility, and curability prior to using them for testing the efficacy of candidate vaccines.
摘要
对于任何受控人体感染模型（CHIM），都需要安全、标准化且具有生物学相关性的挑战接种物。对于丙型肝炎病毒（HCV）CHIM，我们建议使用具有广泛病毒学、血清学和分子特征的几种病毒基因型的人源高滴度接种物作为最合适的方法。在使用这些接种物来测试候选疫苗的疗效之前，应首先以逐步的方式在人类志愿者中进行测试，以确保安全性、可重复性和可治愈性。
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