College of Biomass Science and Engineering, Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China.
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu 610041, China.
Biomacromolecules. 2023 Sep 11;24(9):4218-4228. doi: 10.1021/acs.biomac.3c00536. Epub 2023 Aug 14.
The development of moisturizing, antibacterial, and biocompatible multifunctional hydrogels is essential to protect skin and promote skin defects recovery. Gelatin has admired potential to be applied for skin care as a hydrogel in virtue of its hydrophilic biocompatible and biodegradable properties. In this study, triclosan-grafted gelatin and photo-cross-linkable methacrylated gelatin were synthesized and then combined to construct the semi-interpenetrating network and antibacterial hydrogels with the aid of a visible blue light. The antimicrobial test demonstrated that the resulting hydrogel obtained excellent inactivation capacity against , , , and with sterilizing rates of 99.998%, 99.998%, 99.19%, and 99.64%, respectively. In addition, the cytotoxicity, hemolysis, skin irritation, and rat skin wound healing experiments proved the good biocompatibility of the hydrogel. Therefore, this investigation sheds light on the development of multifunctional hydrogels in skin care.
开发保湿、抗菌和生物相容的多功能水凝胶对于保护皮肤和促进皮肤缺陷的恢复至关重要。明胶由于其亲水性、生物相容性和可生物降解性，具有作为水凝胶应用于皮肤护理的令人钦佩的潜力。在这项研究中，合成了接枝三氯生的明胶和光交联的甲基丙烯酰化明胶，然后借助可见蓝光构建了半互穿网络和抗菌水凝胶。抗菌试验表明，所得水凝胶对 、 、 、 具有优异的灭活能力，杀菌率分别为 99.998%、99.998%、99.19%和 99.64%。此外，细胞毒性、溶血、皮肤刺激和大鼠皮肤伤口愈合实验证明了水凝胶的良好生物相容性。因此，这项研究为皮肤护理多功能水凝胶的发展提供了思路。
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