病例报告：卵形疟原虫感染继发噬血细胞性淋巴组织细胞增生症。
Case Report: Hemophagocytic Lymphohistiocytosis Secondary to Plasmodium ovale wallikeri Infection.
机构信息
Medicina Interna, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
Microbiología y Parasitología Clínica, UGC Laboratorio Análisis Clínicos, Hospital Universitario San Agustín, Linares, Jaén, Spain.
出版信息
Am J Trop Med Hyg. 2023 Aug 14;109(3):608-610. doi: 10.4269/ajtmh.23-0180. Print 2023 Sep 6.
Abstract
We report the first known case of hemophagocytic lymphohistiocytosis (HLH) secondary to imported Plasmodium ovale wallikeri infection in a 58-year-old white woman. A delayed diagnosis of malaria and HLH was made after protracted fever and pancytopenia failed to respond adequately to antimalarial treatment, which required intravenous methylprednisolone and gamma-globulin therapy to resolve.
摘要
我们报告了首例由输入性卵形疟原虫感染引起的噬血细胞性淋巴组织细胞增生症（HLH）病例，患者为 58 岁白人女性。该患者因长期发热和全血细胞减少，抗疟治疗反应不佳，后经诊断为疟疾和 HLH，但诊断被延误，治疗需要静脉注射甲基强的松龙和丙种球蛋白。
相似文献
1
Case Report: Hemophagocytic Lymphohistiocytosis Secondary to Plasmodium ovale wallikeri Infection.病例报告：卵形疟原虫感染继发噬血细胞性淋巴组织细胞增生症。
Am J Trop Med Hyg. 2023 Aug 14;109(3):608-610. doi: 10.4269/ajtmh.23-0180. Print 2023 Sep 6.
2
Rituximab, etoposide, methylprednisolone, high-dose cytarabine, and cisplatin in the treatment of secondary hemophagocytic lymphohistiocytosis with classical Hodgkin lymphoma: a case report and review of the literature.利妥昔单抗、依托泊苷、甲泼尼龙、大剂量阿糖胞苷和顺铂治疗伴经典型霍奇金淋巴瘤的继发性噬血细胞性淋巴组织细胞增生症：1例报告并文献复习
J Med Case Rep. 2016 Dec 20;10(1):365. doi: 10.1186/s13256-016-1143-9.
3
Haemophagocytic lymphohistiocytosis: a cause of unresponsive malaria in a 5-year-old girl.噬血细胞性淋巴组织细胞增生症：一名5岁女童难治性疟疾的病因
Paediatr Int Child Health. 2015;35(4):333-6. doi: 10.1080/20469047.2015.1109227. Epub 2014 Nov 19.
4
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections.进口卵形疟原虫沃氏亚种和卵形疟原虫库氏亚种感染的前瞻性比较多中心研究。
Malar J. 2018 Oct 30;17(1):399. doi: 10.1186/s12936-018-2544-6.
5
Non-falciparum malaria in Dakar: a confirmed case of Plasmodium ovale wallikeri infection.达喀尔的非恶性疟：一例确诊的沃氏卵形疟原虫感染病例。
Malar J. 2016 Aug 24;15(1):429. doi: 10.1186/s12936-016-1485-1.
6
Successful treatment of mycobacterial infection associated hemophagocytic lymphohistiocytosis with etoposide and anti-tuberculous therapy: a case report.成功治疗结核分枝杆菌感染相关性噬血细胞性淋巴组织细胞增生症：病例报告。
BMC Infect Dis. 2020 May 5;20(1):321. doi: 10.1186/s12879-020-05016-4.
7
A cluster of the first reported Plasmodium ovale spp. infections in Peru occuring among returning UN peace-keepers, a review of epidemiology, prevention and diagnostic challenges in nonendemic regions.一组在秘鲁的首次报告的卵形疟原虫 spp. 感染病例发生在返回的联合国维和人员中，对非流行地区的流行病学、预防和诊断挑战进行回顾。
Malar J. 2019 May 22;18(1):176. doi: 10.1186/s12936-019-2809-8.
8
Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline.青蒿琥酯和多西环素治疗的伴有噬血细胞性淋巴组织细胞增生症的重症间日疟脑型疟
Hematol Oncol Stem Cell Ther. 2018 Mar;11(1):34-37. doi: 10.1016/j.hemonc.2016.06.001. Epub 2016 Aug 6.
9
Acute Hepatitis-A Virus Infection as a Rare Cause of Hemophagocytic Lymphohistiocytosis.急性甲型肝炎病毒感染作为噬血细胞性淋巴组织细胞增生症的罕见病因
J Coll Physicians Surg Pak. 2021 Feb;31(2):232-234. doi: 10.29271/jcpsp.2021.02.232.
10
Comparison of imported Plasmodium ovale curtisi and P. ovale wallikeri infections among patients in Spain, 2005-2011.2005 - 2011年西班牙患者中输入性柯氏疟原虫和沃氏疟原虫感染情况的比较
Emerg Infect Dis. 2014 Mar;20(3):409-16. doi: 10.3201/eid2003.130745.
引用本文的文献
1
Plasmodium ovale Malaria in Travelers and Immigrants to the United States: A Case Series.输入美国的旅行者和移民中的卵形疟原虫疟疾：病例系列
Am J Trop Med Hyg. 2024 Oct 22;112(1):66-71. doi: 10.4269/ajtmh.24-0333. Print 2025 Jan 8.
2
A case of severe Plasmodium ovale malaria with acute respiratory distress syndrome and splenic infarction in a male traveller presenting in Italy.一名在意大利就诊的男性旅行者感染严重卵形疟原虫疟疾，并发急性呼吸窘迫综合征和脾梗死。
Malar J. 2024 Apr 4;23(1):93. doi: 10.1186/s12936-024-04911-4.
3
Hemophagocytic lymphohistiocytosis-how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature.噬血细胞性淋巴组织细胞增生症——作为疟疾的并发症，其发病率和严重程度如何？回顾性病例系列和文献复习。
Infection. 2024 Apr;52(2):471-482. doi: 10.1007/s15010-023-02104-w. Epub 2023 Oct 24.
本文引用的文献
1
Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinib.疟原虫性疟疾引起的继发性噬血细胞性淋巴组织细胞增生症用芦可替尼成功治疗。
Int J Infect Dis. 2020 Nov;100:382-385. doi: 10.1016/j.ijid.2020.07.062. Epub 2020 Aug 7.
2
Macrophage activation syndrome in a patient affected by Plasmodium falciparum Aeroport malaria.一名感染恶性疟原虫机场疟疾患者的巨噬细胞活化综合征
Tunis Med. 2019 Feb;97(2):379-382.
3
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults.成人噬血细胞性淋巴组织细胞增生症的治疗建议。
Blood. 2019 Jun 6;133(23):2465-2477. doi: 10.1182/blood.2018894618. Epub 2019 Apr 16.
4
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections.进口卵形疟原虫沃氏亚种和卵形疟原虫库氏亚种感染的前瞻性比较多中心研究。
Malar J. 2018 Oct 30;17(1):399. doi: 10.1186/s12936-018-2544-6.
5
Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon.在加蓬进行的评估蒿甲醚-本芴醇治疗间日疟原虫、卵形疟原虫和混合疟原虫疟疾的种特异性疗效的前瞻性临床试验。
Antimicrob Agents Chemother. 2018 Feb 23;62(3). doi: 10.1128/AAC.01758-17. Print 2018 Mar.
6
Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline.青蒿琥酯和多西环素治疗的伴有噬血细胞性淋巴组织细胞增生症的重症间日疟脑型疟
Hematol Oncol Stem Cell Ther. 2018 Mar;11(1):34-37. doi: 10.1016/j.hemonc.2016.06.001. Epub 2016 Aug 6.
7
Haemophagocytic lymphohistiocytosis (HLH): a rare but potentially fatal association with Plasmodium vivax malaria.噬血细胞性淋巴组织细胞增生症（HLH）：一种与间日疟原虫疟疾相关的罕见但可能致命的病症。
BMJ Case Rep. 2016 Jun 13;2016:bcr2016215366. doi: 10.1136/bcr-2016-215366.
8
Histiocytic disorders: recent insights into pathophysiology and practical guidelines.组织细胞疾病：病理生理学的新见解和实用指南。
Biol Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S82-9. doi: 10.1016/j.bbmt.2009.11.014. Epub 2009 Nov 22.
9
Macrophage activation syndrome in malaria.疟疾中的巨噬细胞活化综合征。
Rheumatol Int. 2010 Jun;30(8):1099-101. doi: 10.1007/s00296-009-1033-1. Epub 2009 Jul 11.
10
Infections associated with haemophagocytic syndrome.与噬血细胞综合征相关的感染
Lancet Infect Dis. 2007 Dec;7(12):814-22. doi: 10.1016/S1473-3099(07)70290-6.
Zotero 插件