Fan Z Y, Chen R, Wei W W
Office for Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhonghua Zhong Liu Za Zhi. 2023 Aug 23;45(8):637-641. doi: 10.3760/cma.j.cn112152-20220516-00337.
Esophageal cancer (EC) is a dreadful disease with a poor prognosis and poses heavy health burden worldwide. Developing effective methods to identify high-risk individuals is urgently needed for preliminary screening before endoscopy. The novel non-endoscopic device has the potential advantages of low cost, simple operation, and minimal invasiveness. Approximately 90% of participants can swallow the device successfully with high safety profiles, and sufficient esophageal exfoliated cells can be collected for cytological examination and biomarker detection. Cytological examination based on the device combined with trefoil factor 3 (TFF3) protein or DNA methylation examinations could effectively screen Barrett's esophagus-associated dysplasia and early esophageal adenocarcinoma, but large prospective studies are needed to further validate the diagnostic value of this device to improve the quality of evidence. Although the device-based cytological examination in combination with biomarker detection holds promise in the early screening of esophageal squamous dysplasia and early esophageal squamous cell carcinoma, related research is still in its infancy, and there is still a lack of sufficient evidence for population screening in China. Active research into the application of this novel non-endoscopic device in EC screening and early diagnosis is of great significance for optimizing EC screening strategies and improving the early diagnosis of EC.
食管癌（EC）是一种预后较差的可怕疾病，在全球范围内造成沉重的健康负担。迫切需要开发有效的方法来识别高危个体，以便在内镜检查前进行初步筛查。这种新型非内镜设备具有成本低、操作简单和侵入性最小的潜在优势。大约90%的参与者能够安全地成功吞咽该设备，并且可以收集到足够的食管脱落细胞用于细胞学检查和生物标志物检测。基于该设备的细胞学检查结合三叶因子3（TFF3）蛋白或DNA甲基化检查可以有效地筛查巴雷特食管相关发育异常和早期食管腺癌，但需要大型前瞻性研究来进一步验证该设备的诊断价值，以提高证据质量。尽管基于该设备的细胞学检查联合生物标志物检测在食管鳞状发育异常和早期食管鳞状细胞癌的早期筛查中具有前景，但相关研究仍处于起步阶段，在中国仍缺乏足够的人群筛查证据。积极研究这种新型非内镜设备在食管癌筛查和早期诊断中的应用，对于优化食管癌筛查策略和提高食管癌的早期诊断具有重要意义。
