Transplantation Center, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Changsha, 410013, Hunan, People's Republic of China.
Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, Changsha, Hunan, People's Republic of China.
Sci Rep. 2023 Aug 14;13(1):13222. doi: 10.1038/s41598-023-40082-z.
Schistosomiasis is a chronic parasitic disease, which affects the quality of daily life of patients and imposes a huge burden on society. Hepatic fibrosis in response to continuous insult of eggs to the liver is a significant cause of morbidity and mortality. However, the mechanisms of hepatic fibrosis in schistosomiasis are largely undefined. The purpose of our study is to detect the indicator to hepatic fibrosis in schistosomiasis. A total of 488 patients with chronic schistosomiasis japonica were enrolled in our study. The patients were divided into two groups according to liver ultrasound examination, which could indicate liver fibrosis of schistosomiasis with unique reticular changes. Logistic regression analysis showed that globulin, albumin/globulin, GGT levels and anti-Schistosoma IgG were independently associated with liver fibrosis in patients with schistosomiasis and IgG was the largest association of liver fibrosis (OR 2.039, 95% CI 1.293-3.213). We further compared IgG+ patients with IgG- patients. IgG+ patients (ALT 25 U/L, GGT 31 U/L) slightly higher than IgG- patients (ALT 22 U/L, GGT 26 U/L) in ALT and GGT. However, the fibrosis of liver in IgG+ patients (Grade II(19.7%), Grade III(7.3%)) were more severe than that in IgG- patients(Grade II(12.5%), Grade III(2.9%)) according to the grade of liver ultrasonography. Our results showed anti-Schistosoma IgG was independently associated with liver fibrosis in patients with chronic schistosomiasis japonica and patients with persistent anti-Schistosoma IgG might have more liver fibrosis than negative patients despite no obvious clinical signs or symptoms.
血吸虫病是一种慢性寄生虫病，影响患者的日常生活质量，并给社会带来巨大负担。肝脏纤维化是对肝脏持续损伤的结果，是发病率和死亡率的重要原因。然而，血吸虫病肝纤维化的确切机制仍不清楚。本研究旨在检测血吸虫病肝纤维化的指标。共纳入 488 例慢性日本血吸虫病患者。根据肝脏超声检查将患者分为两组，肝脏超声检查可提示具有独特网状改变的血吸虫病肝纤维化。Logistic 回归分析显示球蛋白、白蛋白/球蛋白、GGT 水平和抗血吸虫 IgG 与血吸虫病患者的肝纤维化独立相关，而 IgG 与肝纤维化的相关性最大（OR 2.039，95%CI 1.293-3.213）。我们进一步比较了 IgG+患者和 IgG-患者。与 IgG-患者（ALT 22 U/L，GGT 26 U/L）相比，IgG+患者（ALT 25 U/L，GGT 31 U/L）的 ALT 和 GGT 略高。然而，根据肝脏超声检查的分级，IgG+患者（Ⅱ级（19.7%），Ⅲ级（7.3%））的肝脏纤维化程度比 IgG-患者（Ⅱ级（12.5%），Ⅲ级（2.9%））更严重。我们的结果表明，抗血吸虫 IgG 与慢性日本血吸虫病患者的肝纤维化独立相关，尽管没有明显的临床症状或体征，但持续存在抗血吸虫 IgG 的患者可能比阴性患者有更多的肝纤维化。
