Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan.
Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan.
Chem Commun (Camb). 2023 Aug 31;59(71):10660-10663. doi: 10.1039/d3cc03363e.
Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.
哌啶酸衍生物被发现能影响胰岛淀粉样多肽（IAPP）的聚集过程。构效关系研究表明，PAD-13 是一种有效的分子调节剂，能通过促进一级和二级成核以及降低其抗菌活性来加速 IAPP 纤维的形成。
