脑室内注射精氨酸加压素可阻止小鼠对乙醇产生耐受性。
Intraventricular arginine vasopressin blocks the acquisition of ethanol tolerance in mice.
作者信息
Mannix S A, Hoffman P L, Melchior C L
出版信息
Eur J Pharmacol. 1986 Aug 22;128(1-2):137-41. doi: 10.1016/0014-2999(86)90568-6.
PMID:3758185
Abstract
Intracerebroventricular administration of [Arg8]vasopressin (AVP) blocks the development of tolerance to ethanol, when ethanol is administered to mice in a learning paradigm. This effect appears to result from an influence of AVP on both functional and dispositional components of tolerance.
摘要
当在学习范式中给小鼠注射乙醇时，脑室内注射[精氨酸8]加压素（AVP）可阻断对乙醇耐受性的形成。这种效应似乎是由于AVP对耐受性的功能和处置成分均有影响所致。
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