Car H, Borawska M H, Wiśniewski K
Department of Pharmacology, Medical Academy, Białystok, Poland.
J Physiol Pharmacol. 1994 Mar;45(1):163-71.
Rats with impaired active and passive avoidance induced by chronic administration of ethanol were studied. Vasopressin (AVP) and analogue (d(CH2)1(5), Tyr (Me)2, Val4, delta 3Pro7] AVP (icv, 2 micrograms) eliminated the toxic effect of ethanol, and analogue AVP improved retrieval of passive avoidance situation in both control and postalcohol groups of rats. Chronically administered ethanol markedly depressed the ability to learn. AVP administered icv markedly delayed extinction of conditioned avoidance situation in both groups of rats, and did not influence acquisition in this test. Analogue AVP has no influence on extinction and acquisition in the control and post-alcohol groups of rats.
对长期给予乙醇导致主动和被动回避受损的大鼠进行了研究。血管加压素（AVP）及其类似物[d(CH2)1(5), Tyr (Me)2, Val4, delta 3Pro7]AVP（脑室内注射，2微克）消除了乙醇的毒性作用，并且该类似物AVP改善了对照组和乙醇处理后大鼠组被动回避情境的恢复。长期给予乙醇显著降低学习能力。脑室内注射AVP显著延迟了两组大鼠条件性回避情境的消退，并且在该测试中不影响习得。类似物AVP对对照组和乙醇处理后大鼠组的消退和习得均无影响。
