Khan Imran, Steeg Patricia S
Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Building 37, Room 1126, NCI, NIH, Bethesda, MD, 20892, USA.
Cancer Metastasis Rev. 2023 Dec;42(4):1061-1063. doi: 10.1007/s10555-023-10131-0.
Metastasis is the leading cause of cancer patient mortality. Metastasis suppressors are genes that, upon reexpression in metastatic tumor cells to levels observed in their nonmetastatic counterparts, significantly reduce metastasis without affecting the growth of the primary tumor. Analysis of > 30 metastasis suppressors revealed complex mechanisms of action that include multiple signaling pathways, transcriptional patterns, posttranscriptional regulatory mechanisms, and potential contributions of genomic stability. Clinical testing of strategies to re-establish a validated metastasis suppressor pathway in tumors is best directed to the adjuvant setting, with the goal of inhibiting the outgrowth of occult micrometastases.
转移是癌症患者死亡的主要原因。转移抑制基因是指那些在转移性肿瘤细胞中重新表达至与其非转移性对应细胞中所观察到的水平时，能显著降低转移而不影响原发性肿瘤生长的基因。对30多种转移抑制基因的分析揭示了其复杂的作用机制，包括多个信号通路、转录模式、转录后调控机制以及基因组稳定性的潜在作用。在肿瘤中重新建立经过验证的转移抑制基因通路的策略的临床测试，最好针对辅助治疗环境，目标是抑制隐匿性微转移灶的生长。
