University of Washington Medical Center, Seattle, WA, USA.
Histol Histopathol. 2013 Mar;28(3):285-92. doi: 10.14670/HH-28.285.
Metastasis is a major cause of cancer mortality. Metastasis is a complex process that requires the regulation of both metastasis-promoting and metastasis suppressor genes. The discovery of metastasis suppressor genes contributes significantly to our understanding of metastasis mechanisms and provides prognostic markers and therapeutic targets in clinical cancer management. In this review, we summarize the methods that have been used to identify metastasis suppressors and the potential clinical impact of these genes.
转移是癌症死亡的主要原因。转移是一个复杂的过程，需要调节促进转移和抑制转移的基因。转移抑制基因的发现对我们理解转移机制有重要贡献，并为临床癌症管理中的预后标志物和治疗靶点提供了依据。在这篇综述中，我们总结了鉴定转移抑制因子的方法以及这些基因的潜在临床影响。
