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Kynurenines do not antagonise GABA in rat hippocampus.

作者信息

Stone T W

出版信息

Eur J Pharmacol. 1986 Aug 22;128(1-2):81-3. doi: 10.1016/0014-2999(86)90560-1.

DOI:10.1016/0014-2999(86)90560-1
PMID:3758189
Abstract

Kynurenine and kynurenic acid are known to produce convulsions in rats and mice and it has been reported that kynurenine can displace GABA from its neuronal binding sites. The present study shows that neither kynurenine nor kynurenic acid are antagonist of GABA when tested on the rat hippocampal slice preparation. It is therefore unlikely that kynurenine seizures result from the blockade of inhibitory neurotransmission.

摘要

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