College of Pharmacy, Zunyi Medical University, Zunyi 563006, China; Key Lab of the Basic Pharmacology of the Ministry of Education & Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563006, China.
Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland (UQ), Brisbane, QLD 4072, Australia.
Int Immunopharmacol. 2023 Oct;123:110779. doi: 10.1016/j.intimp.2023.110779. Epub 2023 Aug 13.
Skin wound healing is a multifaceted and intricate process involving inflammation, tissue proliferation, and scar formation, all of which are accompanied by the continuous application of mechanical forces. Mechanotransduction is the mechanism by which the skin receives and reacts to physical signals from the internal and external environment, converting them into intracellular biochemical signals. This intricate process relies on specialized proteins known as mechanotransducers, with Piezo1 being a critical mechanosensitive ion channel that plays a central role in this process. This article provides an overview of the structural characteristics of Piezo1 and summarizes its effects on corresponding cells or tissues at different stages of skin trauma, including how it regulates skin sensation and skin-related diseases. The aim is to reveal the potential diagnostic and therapeutic value of Piezo1 in skin trauma and skin-related diseases. Piezo1 has been reported to be a vital mediator of mechanosensation and transduction in various organs and tissues. Given its high expression in the skin, Piezo1, as a significant cell membrane ion channel, is essential in activating intracellular signaling cascades that trigger several cellular physiological functions, including cell migration and muscle contraction. These functions contribute to the regulation and improvement of wound healing.
皮肤创伤愈合是一个多方面且复杂的过程，涉及炎症、组织增生和瘢痕形成，所有这些过程都伴随着持续的机械力作用。机械转导是皮肤接收和对来自内部和外部环境的物理信号做出反应的机制，将它们转化为细胞内的生化信号。这个复杂的过程依赖于专门的蛋白质，称为机械转导蛋白，其中 Piezo1 是一种关键的机械敏感离子通道，在这个过程中发挥着核心作用。本文概述了 Piezo1 的结构特征，并总结了它在皮肤创伤的不同阶段对相应细胞或组织的影响，包括它如何调节皮肤感觉和皮肤相关疾病。目的是揭示 Piezo1 在皮肤创伤和皮肤相关疾病中的潜在诊断和治疗价值。Piezo1 已被报道是各种器官和组织中机械感觉和转导的重要介质。鉴于它在皮肤中的高表达，Piezo1 作为一种重要的细胞膜离子通道，对于激活触发几种细胞生理功能的细胞内信号级联反应至关重要，包括细胞迁移和肌肉收缩。这些功能有助于调节和改善伤口愈合。
