Department of Tuberculosis Department Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, No 507 Zhengmin Road, Shanghai, 200433, China.
Tongji University, No 1239 Siping Road, Shanghai, 200433, China.
Cancer Metastasis Rev. 2023 Sep;42(3):653-659. doi: 10.1007/s10555-023-10128-9. Epub 2023 Aug 16.
It has been demonstrated that scar tissue and fibrosis may increase the likelihood of developing malignancies. Specifically, scar tissue has been linked to the occurrence and progression of lung cancer (LC), though the precise mechanisms necessitate further research for explanation. Lung scarring can stem from various causes, with carcinogenesis on scarring lesions in pulmonary tuberculosis (PTB) being the most frequent (accounting for approximately 75% of cases). Notably, having previously cured, PTB is the second most common risk factor for LC after smoking, with approximately 3% of PTB patients experiencing LC as a secondary condition. This essay will delve into the mechanisms, treatment, and prognosis of tuberculosis scar carcinoma (TSC).
已经证实,疤痕组织和纤维化可能会增加恶性肿瘤的发生几率。具体来说,疤痕组织与肺癌(LC)的发生和发展有关,但确切的机制需要进一步研究来解释。肺部疤痕可能由多种原因引起,其中肺结核(PTB)的疤痕病变致癌最为常见(约占 75%)。值得注意的是,PTB 患者在治愈后,其发生 LC 的风险仅次于吸烟,约有 3%的 PTB 患者会继发 LC。本文将深入探讨结核疤痕癌(TSC)的发病机制、治疗和预后。