Tang Lin-Lin, You Hao-Jun, Lei Jing
Center for Translational Medicine Research on Sensory-Motor Diseases, Yan'an University, Yan'an 716000, China.
Key Laboratory of Yan'an Sports Rehabilitation Medicine, Yan'an 716000, China.
Sheng Li Xue Bao. 2023 Aug 25;75(4):595-603.
Parkinson's disease (PD) is a common neurodegenerative disease characterized by motor symptoms, including bradykinesia, resting tremor, and progressive rigidity. More recently, non-motor symptoms of PD, such as pain, depression and anxiety, and autonomic dysfunction, have attracted increasing attention from scientists and clinicians. As one of non-motor symptoms, pain has high prevalence and early onset feature. Because the mechanism of PD-related pathological pain is unclear, the clinical therapy for treating PD-related pathological pain is very limited, with a focus on relieving the symptoms. This paper reviewed the clinical features, pathogenesis, and therapeutic strategies of PD-related pathological pain and discussed the mechanism of the chronicity of PD-related pathological pain, hoping to provide useful data for the study of drugs and clinical intervention for PD-related pathological pain.
帕金森病（PD）是一种常见的神经退行性疾病，其特征为运动症状，包括运动迟缓、静止性震颤和进行性僵硬。最近，帕金森病的非运动症状，如疼痛、抑郁和焦虑以及自主神经功能障碍，已引起科学家和临床医生越来越多的关注。作为非运动症状之一，疼痛具有高患病率和早发特征。由于帕金森病相关病理性疼痛的机制尚不清楚，治疗帕金森病相关病理性疼痛的临床疗法非常有限，主要侧重于缓解症状。本文综述了帕金森病相关病理性疼痛的临床特征、发病机制和治疗策略，并探讨了帕金森病相关病理性疼痛慢性化的机制，希望为帕金森病相关病理性疼痛的药物研究和临床干预提供有用的数据。
