Department of Neurology, Michigan State University, East Lansing, MI 48824-7015, USA.
Toxins (Basel). 2021 Mar 19;13(3):226. doi: 10.3390/toxins13030226.
Parkinson's disease is the most common age-related motoric neurodegenerative disease. In addition to the cardinal motor symptoms of tremor, rigidity, bradykinesia, and postural instability, there are numerous non-motor symptoms as well. Among the non-motor symptoms, autonomic nervous system dysfunction is common. Autonomic symptoms associated with Parkinson's disease include sialorrhea, hyperhidrosis, gastrointestinal dysfunction, and urinary dysfunction. Botulinum neurotoxin has been shown to potentially improve these autonomic symptoms. In this review, the varied uses of botulinum neurotoxin for autonomic dysfunction in Parkinson's disease are discussed. This review also includes discussion of some additional indications for the use of botulinum neurotoxin in Parkinson's disease, including pain.
帕金森病是最常见的与年龄相关的运动神经元退行性疾病。除了震颤、僵直、运动迟缓、姿势不稳等主要运动症状外，还有许多非运动症状。在非运动症状中，自主神经系统功能障碍较为常见。与帕金森病相关的自主症状包括流涎、多汗、胃肠功能障碍和排尿功能障碍。肉毒毒素已被证明可能改善这些自主症状。本文综述了肉毒毒素在帕金森病自主神经功能障碍中的多种用途。本文还讨论了肉毒毒素在帕金森病中的一些其他适应证，包括疼痛。
