Chilakala Ramakrishna, Moon Hyeon Jeong, Kim Kiwoong, Yang Soyoung, Cheong Sun Hee
Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, Republic of Korea.
Gomari Company, Yeosu, Reublic of Korea.
Phys Act Nutr. 2023 Jun;27(2):50-61. doi: 10.20463/pan.2023.0018. Epub 2023 Jun 30.
In the current study, we investigated the effects of camellia oil and camellia oil infused with herbs (Camellia oleifera Abel) on obesity in obese mice fed a high-fat diet (HFD).
The antioxidant activity of camellia oil in scavenging free radicals was investigated. Additionally, body and organ weight changes, serum and liver marker parameters, antioxidant enzyme activities, liver and epididymal fat histology, protein and gene expression associated with lipogenesis and hyperglycemia effect on adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, were examined in HFD-induced obese mice.
The hepatic steatosis and epididymal fat were significantly reduced by the oral administration of camellia oil and herb-infused camellia oil. Moreover, hepatic and serum marker parameters such as total cholesterol, insulin, triglycerides, tumor necrosis factor-α, adiponectin, thiobarbituric acid reactive substances, aspartate aminotransferase, and alanine transaminase were beneficially impacted. Additionally, the activity of antioxidant enzymes also increased. Camellia oil and herb-infused camellia oil treatments reduced the expression of genes linked to hyperglycemia and lipogenesis via activation of AMPK phosphorylation.
For many people, exercise poses an obstacle in the daily routine due to lack of ease, difficulty in maintaining consistency, and hard work. Camellia oil combined with herbs has anti-obesity and antihyperglycemic effects. These findings indicate that treatment with herb-infused camellia oil is most beneficial for elderly individuals who do not prefer frequent exercise.
在本研究中，我们调查了山茶油以及添加草药的山茶油（油茶）对高脂饮食（HFD）喂养的肥胖小鼠肥胖情况的影响。
研究了山茶油清除自由基的抗氧化活性。此外，在HFD诱导的肥胖小鼠中，检测了体重和器官重量变化、血清和肝脏标志物参数、抗氧化酶活性、肝脏和附睾脂肪组织学、与脂肪生成相关的蛋白质和基因表达以及高血糖对腺苷单磷酸激活蛋白激酶（AMPK）磷酸化的影响。
口服山茶油和添加草药的山茶油可显著减轻肝脏脂肪变性和附睾脂肪。此外，总胆固醇、胰岛素、甘油三酯、肿瘤坏死因子-α、脂联素、硫代巴比妥酸反应性物质、天冬氨酸转氨酶和丙氨酸转氨酶等肝脏和血清标志物参数也受到有益影响。此外，抗氧化酶的活性也有所增加。山茶油和添加草药的山茶油处理通过激活AMPK磷酸化降低了与高血糖和脂肪生成相关基因的表达。
对许多人来说，由于缺乏便利性、难以保持连贯性以及工作量大，运动在日常生活中构成了障碍。山茶油与草药结合具有抗肥胖和抗高血糖作用。这些发现表明，对于不喜欢频繁运动的老年人来说，用添加草药的山茶油进行治疗最为有益。
