Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, China.
The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong, China.
FEMS Microbiol Lett. 2021 Jun 11;368(10). doi: 10.1093/femsle/fnab063.
Obesity, which is often caused by adipocyte metabolism dysfunction, is rapidly becoming a serious global health issue. Studies in the literature have shown that camellia oil (Camellia oleifera Abel) exerted potential lipid regulation and other multiple biological activities. Here, we aimed to investigate the effects of camellia oil on obese mice induced by a high-fat diet and to explore gut microbiota alterations after camellia oil intervention. The results showed that oral administration of camellia oil dramatically attenuated the fat deposits, serum levels of the total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, fasting plasma glucose, the atherosclerosis index, the hepatic steatosis and inflammation in high-fat diet-induced obese mice. Meanwhile, the high-density lipoprotein cholesterol level in obese mice was enhanced after the camellia oil treatment. Furthermore, 16S rRNA analysis showed that certain aspects of the gut microbiota, especially the gut microbiota diversity and the relative abundance of Actinobacteria, Coriobacteriaceae, Lactobacillus and Anoxybacillus, were significantly increased by camellia oil treatment while the ratio of Firmicutes to Bacteroidetes was decreased. Taken together, our finding suggested that camellia oil was a potential dietary supplement and functional food for ameliorating fat deposits, hyperglycemia and fatty liver, probably by modifying the gut microbiota composition.
肥胖症通常是由脂肪细胞代谢功能障碍引起的，它正在迅速成为一个严重的全球健康问题。文献研究表明，油茶籽油（Camellia oleifera Abel）具有潜在的脂质调节和其他多种生物学活性。在这里，我们旨在研究油茶籽油对高脂肪饮食诱导肥胖小鼠的影响，并探讨油茶籽油干预后肠道微生物群的变化。结果表明，油茶籽油口服给药可显著减轻高脂肪饮食诱导肥胖小鼠的脂肪沉积、血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇、空腹血糖、动脉粥样硬化指数、肝脂肪变性和炎症。同时，油茶籽油处理后肥胖小鼠的高密度脂蛋白胆固醇水平升高。此外，16S rRNA 分析表明，肠道微生物群的某些方面，特别是肠道微生物群的多样性和厚壁菌门、柯里氏菌科、乳杆菌属和厌氧杆菌属的相对丰度，经油茶籽油处理后显著增加，而拟杆菌门与厚壁菌门的比例降低。总之，我们的研究结果表明，油茶籽油可能是一种潜在的膳食补充剂和功能性食品，可通过调节肠道微生物群组成来改善脂肪沉积、高血糖和脂肪肝。
