Yuan Cuizhen, Zhang Qian
Heart Center, Peking University People's Hospital, Beijing, China.
Cardiovasc Diagn Ther. 2023 Apr 28;13(2):336-344. doi: 10.21037/cdt-22-385. Epub 2023 Mar 29.
It has been suggested that chronic hypoxia underlies the higher prevalence of microalbuminuria in high-altitude residents than in sea-level dwellers. This study explored the risk factors for microalbuminuria in Tibetans with high-altitude pulmonary hypertension (HAPH).
This retrospective cross-sectional study included adult patients with HAPH admitted to the People's Hospital of Tibet Autonomous Region between November 2018 and August 2019.
One hundred and twenty patients with HAPH were included in this study, and 69 patients (57.5%) had microalbuminuria. Compared with the patients without microalbuminuria, the microalbuminuria group had significantly higher values for age, pulmonary arterial systolic pressure (PASP), systolic blood pressure, diastolic blood pressure, blood hemoglobin concentration, glycated hemoglobin, serum creatinine, and serum uric acid, significantly lower values for heart rate, peripheral oxygen saturation (SpO), estimated glomerular filtration rate, and 6-min walking distance, and poorer New York Heart Association functional class (P<0.05 for all variables). PASP [odds ratio (OR): 1.55; 95% CI: 1.19-2.00; P=0.001] and SpO (OR = 0.78; 95% CI: 0.63-0.97; P=0.02) were independently associated with microalbuminuria.
Higher PASP and lower SpO were independently associated with microalbuminuria in adult Tibetan patients with HAPH.
有人提出，慢性缺氧是高海拔地区居民微量白蛋白尿患病率高于海平面居民的原因。本研究探讨了高原肺动脉高压（HAPH）藏族患者微量白蛋白尿的危险因素。
这项回顾性横断面研究纳入了2018年11月至2019年8月期间入住西藏自治区人民医院的成年HAPH患者。
本研究纳入了120例HAPH患者，其中69例（57.5%）有微量白蛋白尿。与无微量白蛋白尿的患者相比，微量白蛋白尿组患者的年龄、肺动脉收缩压（PASP）、收缩压、舒张压、血红蛋白浓度、糖化血红蛋白、血清肌酐和血清尿酸值显著更高，心率、外周血氧饱和度（SpO）、估计肾小球滤过率和6分钟步行距离值显著更低，纽约心脏协会功能分级更差（所有变量P<0.05）。PASP[比值比（OR）：1.55；95%置信区间（CI）：1.19-2.00；P=0.001]和SpO（OR = 0.78；95%CI：0.63-0.97；P=0.02）与微量白蛋白尿独立相关。
在成年藏族HAPH患者中，较高的PASP和较低的SpO与微量白蛋白尿独立相关。
