血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR）在肺动脉高压患者中的预后价值

Prognostic Value of Platelet to Lymphocyte Ratio (PLR) and Neutrophil to Lymphocyte Ratio (NLR) in Patients with Pulmonary Hypertension.

作者信息

Shahmoradi Zahra, Malekmohammad Majid, Najafi Ghazal, Heshmatnia Jalal, Emami Habib, Ardehali Seyed Hossein, Shojaei Seyedpouzhia, Hashemian Seyed MohammadReza

机构信息

Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Tanaffos. 2022 Apr;21(4):480-486.

PMID:37583772

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10423858/

Abstract

BACKGROUND

Pulmonary hypertension (PH) is a hemodynamic and pathophysiological disease defined by a mean pulmonary artery pressure of ≥20 mm Hg. Pulmonary hypertension severity and prognosis play an essential role in the management of these patients. The aim of this study was to evaluate the prognostic value of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) in patients with PH referred to Masih Daneshvari Hospital, Tehran, Iran.

MATERIALS AND METHODS

A total of 61 patients with PH referred to Masih Daneshvari Hospital in Tehran were enrolled. Patients' information such as age, sex, type of PH, echocardiographic data, and blood cell count, including platelet, lymphocyte, and neutrophil count, hemoglobin, and RDW, were collected in each follow-up.

RESULTS

Out of 61 patients with PH, 27 (44.3%) were male, and 34 (55.7%) were female. The mean age of the patients was 43.19 ± 2.25 years. Our results showed that during hospitalization, PLR decreased from 13.2 to 9.7, and NLR also decreased from 4.49 to 3.08. Neither PLR nor NLR was associated with gender. However, both PLR and NLR showed a significant difference between deceased vs. discharged patients and were significantly lower in the patients who died.

CONCLUSION

Both PLR and NLR decreased during hospitalization in patients with PH, and this decrease was greater in the patients who died, suggesting these indicators as potential prognostic markers for the disease.

摘要

背景

肺动脉高压（PH）是一种血流动力学和病理生理学疾病，定义为平均肺动脉压≥20mmHg。肺动脉高压的严重程度和预后在这些患者的管理中起着至关重要的作用。本研究的目的是评估血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR）对转诊至伊朗德黑兰马西·达内什瓦里医院的肺动脉高压患者的预后价值。

材料与方法

共纳入61例转诊至德黑兰马西·达内什瓦里医院的肺动脉高压患者。在每次随访中收集患者的信息，如年龄、性别、肺动脉高压类型、超声心动图数据以及血细胞计数，包括血小板、淋巴细胞和中性粒细胞计数、血红蛋白和红细胞分布宽度。

结果

61例肺动脉高压患者中，27例（44.3%）为男性，34例（55.7%）为女性。患者的平均年龄为43.19±2.25岁。我们的结果显示，在住院期间，PLR从13.2降至9.7，NLR也从4.49降至3.08。PLR和NLR均与性别无关。然而，PLR和NLR在死亡患者与出院患者之间均显示出显著差异，且在死亡患者中显著更低。