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新型冠状病毒肺炎与疫苗诱导的血栓形成

COVID-19 and Vaccine-Induced Thrombosis.

作者信息

Sharif-Kashani Babak, Shafaghi Shadi, Naghashzadeh Farah, Mohamadnia Abdolreza, Rahdar Mohammad, Hajimoradi Maryam, Noorali Sima

机构信息

Tobacco Prevention and Control Research Center(TPCRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Lung Transplantation Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Tanaffos. 2022 Apr;21(4):413-418.

Abstract

Coronavirus disease 2019 (COVID-19), a highly contagious infectious disease, has had a catastrophic effect on the world's demographics resulting in more than 2.9 million deaths worldwide till January 2021. It can lead to systemic multi-organ complications; in particular, venous and arterial thromboembolism risk is significantly increased. Venous thromboembolism (VTE) occurs in 22.7% of patients with COVID-19 in the ICU and 8% in non-ICU hospitalized patients. Studies evaluating thromboprophylaxis strategies in patients with COVID-19 are needed to improve the prevention of VTE. VTE is the most commonly reported thrombotic complication, with higher incidence rates among critically ill patients. Several vaccines have been licensed and are currently used to combat the COVID-19 pandemic. Also, several cases of vaccine-induced thrombosis have been reported. Vaccination remains the most critical measure to curb the COVID-19 pandemic. There is a broad consensus that the benefits of vaccination greatly outweigh the potential risks of rare vaccine side effects, such as vaccine-induced immune thrombotic thrombocytopenia (VITT). Therefore, the importance of vaccination should be emphasized. This statement aims to focus on VITT.

摘要

2019冠状病毒病(COVID-19)是一种高度传染性的传染病,对全球人口结构产生了灾难性影响,截至2021年1月,全球死亡人数超过290万。它可导致全身性多器官并发症;特别是静脉和动脉血栓栓塞风险显著增加。静脉血栓栓塞(VTE)在ICU的COVID-19患者中发生率为22.7%,在非ICU住院患者中为8%。需要开展评估COVID-19患者血栓预防策略的研究,以改善VTE的预防。VTE是最常报告的血栓形成并发症,在重症患者中发病率更高。几种疫苗已获许可,目前正用于抗击COVID-19大流行。此外,还报告了几例疫苗诱导的血栓形成病例。接种疫苗仍然是遏制COVID-19大流行的最关键措施。人们普遍认为,接种疫苗的益处远远大于罕见疫苗副作用(如疫苗诱导的免疫性血栓性血小板减少症(VITT))的潜在风险。因此,应强调接种疫苗的重要性。本声明旨在关注VITT。

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N Engl J Med. 2021 Jun 3;384(22):2092-2101. doi: 10.1056/NEJMoa2104840. Epub 2021 Apr 9.
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Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.ChAdOx1新冠疫苗接种后的血栓形成和血小板减少症
N Engl J Med. 2021 Jun 3;384(22):2124-2130. doi: 10.1056/NEJMoa2104882. Epub 2021 Apr 9.

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