Meyers C M, Simpson J L, Martin A O, Elias S
Fertil Steril. 1986 Oct;46(4):615-8.
The frequency of neither hypermodal cells (2N = 47) nor hypomodal cells (2N = 45) differed between lymphocytes of individuals experiencing repetitive spontaneous abortions (N = 429) and controls (N = 90). The same conclusion held when data were analyzed according to chromosome involved (sex chromosome, autosome) or other variables (e.g., prior reproductive outcome). A study of this relatively large sample failed to confirm findings of smaller and sometimes uncontrolled studies. Hypermodal cells do not necessarily serve as a clue to meiotic instability and in turn probably do not identify couples at risk for recurrent aneuploidy.
经历反复自然流产的个体（N = 429）与对照组（N = 90）的淋巴细胞中，超二倍体细胞（2N = 47）和亚二倍体细胞（2N = 45）的频率均无差异。根据涉及的染色体（性染色体、常染色体）或其他变量（例如既往生殖结局）分析数据时，得出了相同的结论。对这个相对大样本的研究未能证实较小规模且有时未设对照的研究结果。超二倍体细胞不一定是减数分裂不稳定的线索，因此可能无法识别有反复非整倍体风险的夫妇。
