复发性自然流产患者淋巴细胞有丝分裂不分离频率增加。
Increased frequency of lymphocytic mitotic non-disjunction in recurrent spontaneous aborters.
作者信息
Juberg R C, Knops J, Mowrey P N
出版信息
J Med Genet. 1985 Feb;22(1):32-5. doi: 10.1136/jmg.22.1.32.
Abstract
Hypermodal chromosomal spreads occurred significantly more frequently in lymphocytes from couples with recurrent spontaneous abortion than from comparison populations. Previously, we reported a similarly increased frequency in couples with aneuploid offspring. Considering the frequency of aneuploidy among first trimester spontaneous abortions, we suggest that there may be a sub-population of persons predisposed to non-disjunction among couples with reproductive wastage.
摘要
与对照人群相比，反复自然流产夫妇的淋巴细胞中出现超模态染色体铺展的频率显著更高。此前，我们报道过非整倍体后代夫妇中也有类似的频率增加情况。考虑到孕早期自然流产中非整倍体的频率，我们认为在有生殖损耗的夫妇中，可能存在一个易发生不分离的亚人群。
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本文引用的文献
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Leukocyte chromosomes from parents of cytogenetically abnormal offspring: preliminary observations.细胞遗传学异常后代父母的白细胞染色体：初步观察
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