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复发性自然流产患者淋巴细胞有丝分裂不分离频率增加。

Increased frequency of lymphocytic mitotic non-disjunction in recurrent spontaneous aborters.

作者信息

Juberg R C, Knops J, Mowrey P N

出版信息

J Med Genet. 1985 Feb;22(1):32-5. doi: 10.1136/jmg.22.1.32.

DOI:10.1136/jmg.22.1.32
PMID:4039006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1049374/
Abstract

Hypermodal chromosomal spreads occurred significantly more frequently in lymphocytes from couples with recurrent spontaneous abortion than from comparison populations. Previously, we reported a similarly increased frequency in couples with aneuploid offspring. Considering the frequency of aneuploidy among first trimester spontaneous abortions, we suggest that there may be a sub-population of persons predisposed to non-disjunction among couples with reproductive wastage.

摘要

与对照人群相比，反复自然流产夫妇的淋巴细胞中出现超模态染色体铺展的频率显著更高。此前，我们报道过非整倍体后代夫妇中也有类似的频率增加情况。考虑到孕早期自然流产中非整倍体的频率，我们认为在有生殖损耗的夫妇中，可能存在一个易发生不分离的亚人群。

相似文献

1
Increased frequency of lymphocytic mitotic non-disjunction in recurrent spontaneous aborters.复发性自然流产患者淋巴细胞有丝分裂不分离频率增加。
J Med Genet. 1985 Feb;22(1):32-5. doi: 10.1136/jmg.22.1.32.
2
Aneuploidy in recurrent spontaneous aborters: the tendency to parental nondisjunction.
Clin Genet. 1984 Jul;26(1):43-5. doi: 10.1111/j.1399-0004.1984.tb00786.x.
3
X chromosome aneuploidy in lymphocyte cultures from women with recurrent spontaneous abortions.
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4
Hypermodal cells, hypomodal cells, and repetitive abortions.高模态细胞、低模态细胞与反复流产
Fertil Steril. 1986 Oct;46(4):615-8.
5
Is there a predisposition for meiotic nondisjunction that may be detected by mitotic hyperploidy?
Clin Genet. 1983 Sep;24(3):184-90.
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Cytogenetic findings in 318 couples with repeated spontaneous abortion: a review of experience in British Columbia.318对反复自然流产夫妇的细胞遗传学研究结果：不列颠哥伦比亚省经验回顾
Am J Med Genet. 1984 Mar;17(3):615-20. doi: 10.1002/ajmg.1320170310.
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The association between sporadic somatic parental aneuploidy and chromosomally abnormal placentae in habitual abortions.散发性体细胞亲本非整倍体与习惯性流产中染色体异常胎盘之间的关联。
Early Pregnancy (Cherry Hill). 2001 Jul;5(3):153-63.
8
Chromosomal analysis in Japanese couples with repeated spontaneous abortions.对反复自然流产的日本夫妇进行的染色体分析。
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A cytogenetic study of repeated spontaneous abortions.反复自然流产的细胞遗传学研究。
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10
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引用本文的文献

1
Replication asynchrony increases in women at risk for aneuploid offspring.染色体数目异常后代风险较高的女性中，复制异步性增加。
Chromosome Res. 2000;8(2):141-50. doi: 10.1023/a:1009246603868.
2
Increased spindle resistance to antimicrotubule agents in women of high risk for meiotic nondisjunction.减数分裂非整倍体高风险女性的纺锤体对抗微管药物的抗性增加。
Hum Genet. 1986 Jul;73(3):199-204. doi: 10.1007/BF00401227.
3
The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history.培养淋巴细胞中染色体数目异常的频率与年龄和性别相关，但与生殖史无关。
Am J Hum Genet. 1990 Jun;46(6):1101-11.

本文引用的文献

1
Anatomic and chromosomal anomalies in 639 spontaneous abortuses.639例自然流产的解剖学和染色体异常情况。
Hum Genet. 1980;55(1):87-98. doi: 10.1007/BF00329132.
2
Leukocyte chromosomes from parents of cytogenetically abnormal offspring: preliminary observations.细胞遗传学异常后代父母的白细胞染色体：初步观察
Cytogenet Cell Genet. 1981;30(1):50-3. doi: 10.1159/000131588.
3
Paternal age and Down syndrome in British Columbia.不列颠哥伦比亚省的父亲年龄与唐氏综合征
Am J Hum Genet. 1981 Jan;33(1):123-8.
4
Genetic services in the United States.美国的基因服务。
JAMA. 1982 Oct 8;248(14):1733-5.
5
Socioeconomic and reproductive characteristics of the parents of patients with the G1-trisomy syndrome.G1-三体综合征患者父母的社会经济和生殖特征。
Soc Biol. 1973 Dec;20(4):404-15. doi: 10.1080/19485565.1973.9988070.
6
A rapid banding technique for human chromosomes.一种用于人类染色体的快速显带技术。
Lancet. 1971 Oct 30;2(7731):971-2. doi: 10.1016/s0140-6736(71)90287-x.
7
High resolution of human chromosomes.人类染色体的高分辨率。
Science. 1976 Mar 26;191(4233):1268-70. doi: 10.1126/science.1257746.
8
Down syndrome and recent demographic trends in Manitoba.唐氏综合征与曼尼托巴省近期的人口趋势。
J Med Genet. 1978 Feb;15(1):43-7. doi: 10.1136/jmg.15.1.43.