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系统性肥大细胞增多症:反应性关节炎的一种模仿者。

Systemic Mastocytosis: A Mimicker of Reactive Arthritis.

作者信息

Nasrallah Oussama G, Mohty Razan, El-Cheikh Jean, Merashli Mira

机构信息

Division of Urology, Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon.

Division of Hematology, Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

出版信息

Case Rep Rheumatol. 2023 Aug 7;2023:6655005. doi: 10.1155/2023/6655005. eCollection 2023.

DOI:10.1155/2023/6655005
PMID:37584057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10425246/
Abstract

OBJECTIVES

Illustration of a case of systemic mastocytosis mimicking reactive arthritis in the absence of an infectious etiology.

METHODS

Review of the patient's medical records.

RESULTS

We report a case of systemic mastocytosis relapse, presenting with pancytopenia accompanied by knee monoarthritis, cystitis, and bilateral conjunctivitis occurring simultaneously at the same time interval within 2-4 days, mimicking reactive arthritis in the absence of an infectious etiology.

CONCLUSION

Our case demonstrated reactive arthritis features (triad of urethritis, conjunctivitis, and arthritis) without an infectious trigger but rather a relapse of mastocytosis. We should think outside the box when faced with such a clinical scenario in the absence of an infectious etiology. Paraneoplastic reactive arthritis is to be considered after excluding an underlying infection.

摘要

目的

举例说明一例在无感染病因情况下酷似反应性关节炎的系统性肥大细胞增多症病例。

方法

回顾患者的病历。

结果

我们报告一例系统性肥大细胞增多症复发病例,表现为全血细胞减少,同时在2 - 4天的相同时间间隔内出现膝关节单关节炎、膀胱炎和双侧结膜炎,在无感染病因的情况下酷似反应性关节炎。

结论

我们的病例显示出反应性关节炎的特征(尿道炎、结膜炎和关节炎三联征),但无感染诱因,而是肥大细胞增多症复发。当面对无感染病因的这种临床情况时,我们应跳出框框思考。排除潜在感染后应考虑副肿瘤性反应性关节炎。

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本文引用的文献

1
Reactive Arthritis: Treatment Challenges and Future Perspectives.反应性关节炎:治疗挑战与未来展望。
Curr Rheumatol Rep. 2020 May 26;22(7):29. doi: 10.1007/s11926-020-00904-9.
2
How we diagnose and treat systemic mastocytosis in adults.我们如何诊断和治疗成人系统性肥大细胞增多症。
Br J Haematol. 2018 Jan;180(1):11-23. doi: 10.1111/bjh.14967. Epub 2017 Oct 19.
3
HLA B27 antigen in Middle Eastern and Arab countries: systematic review of the strength of association with axial spondyloarthritis and methodological gaps.中东和阿拉伯国家的人类白细胞抗原B27抗原:与轴性脊柱关节炎关联强度的系统评价及方法学差距
BMC Musculoskelet Disord. 2017 Jun 29;18(1):280. doi: 10.1186/s12891-017-1639-5.
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Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.肥大细胞增多症的分类与治疗进展:现状与未来展望
Cancer Res. 2017 Mar 15;77(6):1261-1270. doi: 10.1158/0008-5472.CAN-16-2234. Epub 2017 Mar 2.
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Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial.联合使用抗生素治疗慢性衣原体诱导的反应性关节炎:一项双盲、安慰剂对照的前瞻性试验。
Arthritis Rheum. 2010 May;62(5):1298-307. doi: 10.1002/art.27394.
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Reactive arthritis: clinical aspects and medical management.反应性关节炎:临床特征与药物治疗
Rheum Dis Clin North Am. 2009 Feb;35(1):21-44. doi: 10.1016/j.rdc.2009.03.010.
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Reactive arthritis.反应性关节炎
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