Department of Laboratory Medicine, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, China.
Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Hum Vaccin Immunother. 2023 Aug 1;19(2):2245723. doi: 10.1080/21645515.2023.2245723.
Human papillomavirus (HPV) infection is the primary cause of cervical cancer and its precursor lesions. The overall prevalence of HPV genotypes in Changzhou has previously been reported. However, the distribution of multiple HPV infections and their roles in cervical injury have less been investigated. We aimed to assess the prevalence of multiple HPV infections among the people in Changzhou. Furthermore, we analyzed whether multiple HPV infections comprising the top five prevalent HPVs were more associated with abnormalities in E6 and E7 (E6/E7) mRNA, liquid-based cytology, and cervical histopathology than a single infection. In the current study, HPV 16, 52, 58, 53, and 81 were the top five prevalent HPV types, both in single and multiple infections. Compared to a single infection, multiple infections containing HPV 16/52/58 were closely linked to positivity for E6/E7 mRNA. In addition to HPV 16, multiple infections containing the remaining top four HPVs conferred a significant advantage on atypical squamous cells of undermined significance or worse in comparison to a single infection. Furthermore, women with multiple infections containing the top five prevalent HPV types were more likely to develop cervical intraepithelial neoplasia grade II or worse than those with a single HPV infection. Our results demonstrate the superiority of multiple HPV infections containing the top five prevalent HPV types in cervical disease progression, which should be closely monitored. These findings are conducive for formulating regional preventive strategies for cervical cancer screening and vaccination in Changzhou.
人乳头瘤病毒（HPV）感染是宫颈癌及其前体病变的主要原因。此前已经报道了常州 HPV 基因型的总体流行率。然而，对于多重 HPV 感染的分布及其在宫颈损伤中的作用研究较少。我们旨在评估常州人群中多重 HPV 感染的流行率。此外，我们分析了包含前五种最常见 HPV 的多重 HPV 感染是否比单一感染更与 E6 和 E7（E6/E7）mRNA、液基细胞学和宫颈组织病理学异常相关。在本研究中，HPV 16、52、58、53 和 81 是单一和多重感染中最常见的五种 HPV 类型。与单一感染相比，包含 HPV 16/52/58 的多重感染与 E6/E7 mRNA 阳性密切相关。除 HPV 16 外，与单一感染相比，包含其余四种最高 HPV 的多重感染显著增加了意义不明确的非典型鳞状细胞或更差的非典型鳞状细胞的检出率。此外，与单一 HPV 感染相比，感染包含前五种最常见 HPV 类型的多重 HPV 的女性更有可能发展为宫颈上皮内瘤变 II 级或更高级别病变。我们的研究结果表明，包含前五种最常见 HPV 类型的多重 HPV 感染在宫颈疾病进展中具有优势，应密切监测。这些发现有助于制定常州宫颈癌筛查和疫苗接种的区域性预防策略。
