Wang Yaping, Wang Zhiheng, Qu Wenjie, Chen Fang, Wang Yan, Shi Wenqian, Gong Yingxin, Zhou Qi, Mo Jiayin, Lin Lin, Bi Tianyi, Chen Fangying, Sui Long, Li Yanyun
Department of Gynecology and Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
J Med Virol. 2025 Apr;97(4):e70312. doi: 10.1002/jmv.70312.
Human papillomavirus 52 (HPV52) is the second most frequent HPV type in high-grade squamous intraepithelial lesion (HSIL) cases in China. However, few researchers have explored the co-infection of HPV52 with other HPV genotypes and their correlation with cervical lesions. In this study, 13,809 HPV52-positive patients visiting the Obstetrics and Gynecology Hospital of Fudan University from 2018 to 2023 were included in the first stage to investigate the risk of cervical lesions among different multiple infection patterns. Another 443 HPV52-positive patients were further included for sequence alignment and phylogenetic analysis. In the current study, the most common HPV52 dual-infection patterns were as follows: HPV16 + HPV52, HPV52 + HPV58, HPV52 + HPV53, and HPV52 + HPV81. Compared with HPV52 single infection, the risk of HSIL+ was increased in HPV16 + HPV52 (OR = 3.47, 95% CI: 2.56, 4.69) and HPV52 + HPV58 (OR = 1.99, 95% CI: 1.35, 2.92) groups. The most common triple-infection patterns were HPV16 + HPV52 + HPV53 and HPV52 + HPV53 + HPV81, followed by HPV52 + HPV53 + HPV58. HPV53 was the most common co-infection type with HPV52 in cases of triple or more multiple infections. However, compared with dual infection, the addition of HPV53 did not affect the risk of HSIL+. Two synonymous mutations, G207A (p = 0.029) and C1203T (p = 0.021), showed statistically significant differences in distribution between single and multiple infection groups. Our results demonstrated that HPV52 showed preferences for co-infection with HPV16, 585,381. HPV52 co-infection with HPV16 and HPV58 increased the risk of HSIL+, while co-infection with HPV53 did not increase the risk of HSIL+. Virus variants with certain mutations may be more susceptible to multiple infections.
人乳头瘤病毒52型（HPV52）是中国高级别鳞状上皮内病变（HSIL）病例中第二常见的HPV类型。然而，很少有研究人员探讨HPV52与其他HPV基因型的合并感染情况及其与宫颈病变的相关性。在本研究中，第一阶段纳入了2018年至2023年期间前往复旦大学附属妇产科医院就诊的13809例HPV52阳性患者，以调查不同多重感染模式下宫颈病变的风险。另外443例HPV52阳性患者被进一步纳入进行序列比对和系统发育分析。在本研究中，最常见的HPV52双重感染模式如下：HPV16 + HPV52、HPV52 + HPV58、HPV52 + HPV53和HPV52 + HPV81。与HPV52单一感染相比，HPV16 + HPV52（OR = 3.47，95%CI：2.56，4.69）和HPV52 + HPV58（OR = 1.99，95%CI：1.35，2.92）组中HSIL+的风险增加。最常见的三重感染模式为HPV16 + HPV52 + HPV53和HPV52 + HPV53 + HPV81，其次是HPV52 + HPV53 + HPV58。在三重及以上多重感染病例中，HPV53是与HPV52最常见的合并感染类型。然而，与双重感染相比，HPV53的加入并未影响HSIL+的风险。两个同义突变，G207A（p = 0.029）和C1203T（p = 0.021），在单一感染组和多重感染组之间的分布显示出统计学上的显著差异。我们的结果表明，HPV52倾向于与HPV16、58、53、81合并感染。HPV52与HPV16和HPV58合并感染会增加HSIL+的风险，而与HPV53合并感染则不会增加HSIL+的风险。具有某些突变的病毒变体可能更容易发生多重感染。
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