Medical Director Electrophysiology, Electrophysiology - Cardiovascular Group, HCA Florida Miami, Miami, FL 33133, USA.
Johnson & Johnson Medical Devices, Franchise Health Economics and Market Access, Irvine, CA 92618, USA.
J Comp Eff Res. 2023 Sep;12(9):e230005. doi: 10.57264/cer-2023-0005. Epub 2023 Aug 16.
The objective of this study was to indirectly compare QDOT MICRO™ (QDOT), Thermocool SmartTouch™ (ST) and Thermocool SmartTouch Surround Flow (STSF) to treat paroxysmal atrial fibrillation. Differences in baseline characteristics between study cohorts were reduced by reweighting patients using inverse probability of treatment weighting. The primary outcome was procedure time. Secondary outcomes were fluoroscopy time, clinical success at 12 months, and rhythm monitoring-adjusted recurrence. QDOT was associated with significantly faster mean procedure and fluoroscopy time, and significant improvement in the rate of recurrence compared with pooled ST/STSF. No difference was observed for clinical success at 12 months. QDOT was associated with greater efficiency, greater effectiveness in rhythm monitoring-adjusted recurrence and similar effectiveness in clinical success at 12 months compared with pooled ST/STSF.
本研究的目的是间接比较 QDOT MICRO™（QDOT）、Thermocool SmartTouch™（ST）和 Thermocool SmartTouch Surround Flow（STSF）治疗阵发性心房颤动的效果。通过使用逆概率治疗加权（inverse probability of treatment weighting）对研究队列之间的基线特征差异进行重新加权，以减少差异。主要结果是手术时间。次要结果是透视时间、12 个月时的临床成功率和节律监测调整后的复发率。与 pooled ST/STSF 相比，QDOT 与平均手术和透视时间显著缩短、复发率显著降低有关。12 个月时的临床成功率无差异。与 pooled ST/STSF 相比，QDOT 与更高的效率、节律监测调整后的复发效果和相似的 12 个月时的临床成功率有关。
