Department of Physiology, School of Basic Medical Sciences, Hubei University of Science & Technology, Xianning, 437100, China.
Department of Pharmaceutics, School of Pharmacy, Hubei University of Science & Technology, Xianning, 437100, China.
Future Microbiol. 2023 Sep;18:911-916. doi: 10.2217/fmb-2023-0090. Epub 2023 Aug 16.
HSV can evade host defenses and cause lifelong infection and severe illness. Lysosomes are catabolic organelles that play an important role in the regulation of cellular homeostasis. Lysosomal dysfunction and alterations in the process of autophagy have been identified in a variety of diseases, including HSV infection, and targeting lysosomes is a potential anti-HSV therapeutic strategy. This article reviews the role of lysosomes and lysosome-associated proteins in HSV infection, providing attractive targets and novel strategies for the treatment of HSV infection.
单纯疱疹病毒可以逃避宿主防御，导致终身感染和严重疾病。溶酶体是一种分解代谢细胞器，在细胞内稳态的调节中起着重要作用。溶酶体功能障碍和自噬过程的改变已在多种疾病中得到证实，包括单纯疱疹病毒感染，靶向溶酶体是一种有潜力的抗单纯疱疹病毒治疗策略。本文综述了溶酶体及其相关蛋白在单纯疱疹病毒感染中的作用，为单纯疱疹病毒感染的治疗提供了有吸引力的靶点和新策略。
