Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Institute of Clinical Pharmacology, Central South University, Changsha, China.
Biomed Pharmacother. 2023 Sep;165:115121. doi: 10.1016/j.biopha.2023.115121. Epub 2023 Jul 5.
Redox homeostasis refers to the dynamic equilibrium between oxidant and reducing agent in the body which plays a crucial role in maintaining normal physiological activities of the body. The imbalance of redox homeostasis can lead to the development of various human diseases. Lysosomes regulate the degradation of cellular proteins and play an important role in influencing cell function and fate, and lysosomal dysfunction is closely associated with the development of various diseases. In addition, several studies have shown that redox homeostasis plays a direct or indirect role in regulating lysosomes. Therefore, this paper systematically reviews the role and mechanisms of redox homeostasis in the regulation of lysosomal function. Therapeutic strategies based on the regulation of redox exerted to disrupt or restore lysosomal function are further discussed. Uncovering the role of redox in the regulation of lysosomes helps to point new directions for the treatment of many human diseases.
氧化还原平衡是指体内氧化剂和还原剂之间的动态平衡，对于维持身体正常的生理活动起着至关重要的作用。氧化还原平衡的失衡可能导致各种人类疾病的发生。溶酶体调节细胞内蛋白质的降解，在影响细胞功能和命运方面发挥着重要作用，溶酶体功能障碍与各种疾病的发生密切相关。此外，有几项研究表明，氧化还原平衡在调节溶酶体方面发挥着直接或间接的作用。因此，本文系统地综述了氧化还原平衡在调节溶酶体功能中的作用和机制。还进一步讨论了基于氧化还原调节的治疗策略，以破坏或恢复溶酶体功能。揭示氧化还原在调节溶酶体中的作用有助于为治疗许多人类疾病指明新的方向。
