脂肪酸诱导的溶血。铜蓝蛋白、白蛋白、硫醇和维生素C的保护作用。

Fatty acid induced hemolysis. Protective action of ceruloplasmin, albumins, thiols and vitamin C.

作者信息

Løvstad R A

出版信息

Int J Biochem. 1986;18(9):771-5. doi: 10.1016/0020-711x(86)90052-2.

Abstract

The hemolytic effect of saturated fatty acids increased rapidly, when the number of carbon atoms in the chain exceeded 12. At low fatty acid concentrations (less than 60 microM) the hemolytic effect decreased with increasing number of double bonds in the carbon chain (cis-form fatty acids). A more complex pattern was observed at higher fatty acid concentrations. Trans-unsaturated fatty acids were more hemolytic than cis-analogs. Ceruloplasmin, a serum protein with no fatty acid binding capacity, reduced the hemolytic effect of fatty acids; possibly by interacting with the cell membrane. Reducing compounds (thiols, vitamin C) also protected against fatty acid induced hemolysis.

摘要

当链中的碳原子数超过12时，饱和脂肪酸的溶血作用迅速增强。在低脂肪酸浓度（小于60微摩尔）下，溶血作用随着碳链中双键数量的增加（顺式脂肪酸）而降低。在较高脂肪酸浓度下观察到更复杂的模式。反式不饱和脂肪酸比顺式类似物更具溶血作用。铜蓝蛋白是一种没有脂肪酸结合能力的血清蛋白，它降低了脂肪酸的溶血作用；可能是通过与细胞膜相互作用。还原性化合物（硫醇、维生素C）也能防止脂肪酸诱导的溶血。