白癜风患者自身免疫性萎缩性胃炎的患病率。

Prevalence of autoimmune atrophic gastritis in vitiligo.

作者信息

Zauli D, Tosti A, Biasco G, Miserocchi F, Patrizi A, Azzaroni D, Andriani G, Di Febo G, Callegari C

出版信息

Digestion. 1986;34(3):169-72. doi: 10.1159/000199325.

DOI:10.1159/000199325

Abstract

Gastric biopsies, and measurements of fasting serum gastrin levels and titers of antihuman parietal cell antibodies have been performed in 65 unselected patients with vitiligo. Histologic evidence of autoimmune atrophic gastritis has been obtained in 10 cases (15%), who were all positive for the antibodies and who had elevated gastrin levels. The study of gastric secretion after pentagastrin stimulation, performed in 7 of these patients, showed a markedly reduced acid output. The present study provides definite evidence of the association of autoimmune atrophic gastritis with a proportion of vitiligo cases and suggests the need for surveillance of these patients in terms of gastric neoplasia.

摘要

对65例未经挑选的白癜风患者进行了胃活检、空腹血清胃泌素水平测定及抗人壁细胞抗体滴度检测。10例（15%）患者获得了自身免疫性萎缩性胃炎的组织学证据，这些患者抗体均呈阳性，胃泌素水平升高。对其中7例患者进行了五肽胃泌素刺激后胃分泌的研究，结果显示胃酸分泌明显减少。本研究提供了自身免疫性萎缩性胃炎与部分白癜风病例相关的明确证据，并提示需要对这些患者进行胃癌方面的监测。