TLR2 和 TLR9 基因中的同义突变降低了中国汉族人群 COPD 的易感性。
Synonymous mutations in TLR2 and TLR9 genes decrease COPD susceptibility in the Chinese Han population.
机构信息
Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China.
Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China.
出版信息
Pulmonology. 2024 May-Jun;30(3):230-238. doi: 10.1016/j.pulmoe.2022.09.010. Epub 2022 Oct 27.
INTRODUCTION
Previous studies have found associations between polymorphisms in some candidate genes and chronic obstructive pulmonary disease (COPD) risk. However, the association between TLR2 and TLR9 polymorphisms and COPD risk remains uncertain.
METHODS
Four variants (rs352140, rs3804099, rs3804100, and rs5743705) of the TLR2 and TLR9 genes in 540 COPD patients and 507 healthy controls were genotyped using the Agena MassARRAY system. Odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the association of TLR2 and TLR9 polymorphisms with COPD risk by logistic regression analysis.
RESULTS
TLR9-rs352140, TLR2-rs3804100, and TLR2-rs5743705 were related to a lower risk of COPD among Chinese people and the significance still existed after Bonferroni correction. Additionally, rs3804099, rs3804100, and rs352140 were found to be associated with COPD development in different subgroups (males, age ≤ 68 years, smokers, BMI < 24 kg/m, and acute exacerbation).
CONCLUSIONS
Our findings indicated that TLR9 and TLR2 polymorphisms had protective effects on the development of COPD among Chinese people.
简介
先前的研究发现，一些候选基因的多态性与慢性阻塞性肺疾病（COPD）风险之间存在关联。然而，TLR2 和 TLR9 多态性与 COPD 风险之间的关联仍不确定。
方法
使用 Agena MassARRAY 系统对 540 例 COPD 患者和 507 例健康对照者的 TLR2 和 TLR9 基因的 4 个变体（rs352140、rs3804099、rs3804100 和 rs5743705）进行基因分型。通过 logistic 回归分析计算比值比（OR）和 95%置信区间（CI），以评估 TLR2 和 TLR9 多态性与 COPD 风险的关联。
结果
TLR9-rs352140、TLR2-rs3804100 和 TLR2-rs5743705 与中国人 COPD 风险降低相关，且在 Bonferroni 校正后仍具有统计学意义。此外，rs3804099、rs3804100 和 rs352140 与不同亚组（男性、年龄≤68 岁、吸烟者、BMI<24kg/m 和急性加重期）的 COPD 发生相关。
结论
我们的研究结果表明，TLR9 和 TLR2 多态性对中国人 COPD 的发生具有保护作用。
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