Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan.
Crit Rev Ther Drug Carrier Syst. 2023;40(6):89-116. doi: 10.1615/CritRevTherDrugCarrierSyst.2023042400.
The liver is one of the crucial organs of the body that performs hundreds of chemical reactions needed by the body to survive. It is also the largest gland of the body. The liver has multiple functions, including the synthesis of chemicals, metabolism of nutrients, and removal of toxins. It also acts as a storage unit. The liver has a unique ability to regenerate itself, but it can lead to permanent damage if the injury is beyond recovery. The only possible treatment of severe liver damage is liver transplant which is a costly procedure and has several other drawbacks. Therefore, attention has been shifted towards the use of stem cells that have shown the ability to differentiate into hepatocytes. Among the numerous kinds of stem cells (SCs), the mesenchymal stem cells (MSCs) are the most famous. Various studies suggest that an MSC transplant can repair liver function, improve the signs and symptoms, and increase the chances of survival. This review discusses the impact of combining stem cell therapy with nanotechnology. By integrating stem cell science and nanotechnology, the information about stem cell differentiation and regulation will increase, resulting in a better comprehension of stem cell-based treatment strategies. The augmentation of SCs with nanoparticles has been shown to boost the effect of stem cell-based therapy. Also, the function of green nanoparticles in liver therapies is discussed.
肝脏是人体的重要器官之一，它执行着人体生存所需的数百种化学反应。它也是人体最大的腺体。肝脏具有多种功能，包括化学物质的合成、营养物质的代谢和毒素的清除。它还起到储存单元的作用。肝脏具有自我再生的独特能力，但如果损伤超出了恢复的范围，可能会导致永久性损伤。严重肝损伤的唯一可能治疗方法是肝移植，这是一种昂贵的程序，还有其他几个缺点。因此，人们已经将注意力转向使用已经显示出分化为肝细胞能力的干细胞。在众多种类的干细胞（SCs）中，间充质干细胞（MSCs）最为著名。各种研究表明，MSC 移植可以修复肝功能，改善症状，并提高存活率。本综述讨论了将干细胞疗法与纳米技术结合的影响。通过整合干细胞科学和纳米技术，将增加关于干细胞分化和调节的信息，从而更好地理解基于干细胞的治疗策略。已经证明，用纳米粒子增强 SCs 可以增强基于干细胞的治疗效果。此外，还讨论了绿色纳米粒子在肝脏治疗中的作用。
