Intatham Supaporn, Taychaworaditsakul Weerakit, Kunnaja Phraepakaporn, Wongnoppavich Ariyaphong, Jaijoy Kanjana, Chansakaow Sunee, Rojsanga Piyanuch, Sireeratawong Seewaboon
Clinical Research Center for Food and Herbal Product Trials and Development (CR-FAH), Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Pharmaceuticals (Basel). 2025 May 5;18(5):685. doi: 10.3390/ph18050685.
The present study aims to evaluate the anti-hangover and hepatoprotective activities of the leaf extract of in experimental animals. Two experiments were conducted that involved giving a single dose of the leaf extract of (1, 10, or 100 mg/kg body weight) to rats 30 min either before or after administration of 40% ethanol (5 g/kg body weight). The locomotor activity of the rats was measured before and after receiving the test substances. Blood samples were collected to determine the ethanol, acetate, and liver enzyme levels. Liver tissues were collected to evaluate alcohol-metabolizing enzymes, antioxidant enzyme activities, and antioxidant levels. Administration of the leaf extract of to the rats prior to ethanol increased locomotor activity and reduced blood ethanol levels. The extract also prevented changes in liver enzyme levels and demonstrated antioxidant activity by scavenging free radicals resulting from ethanol-induced oxidative stress. Conversely, rats administered the leaf extract of after receiving ethanol were able to reduce the elevated liver enzyme levels back to normal levels, and probably helped to inhibit the harmful effects of free radicals by stimulating the synthesis and/or activities of antioxidant enzymes. Administration of the leaf extract of either before or after ethanol exposure was able to reduce the activity of an alcohol-metabolizing enzyme as well as reduce blood acetate levels. In summary, receiving the leaf extract of before alcohol consumption could probably help to reduce hangover symptoms and was shown to have hepatoprotective effects superior to receiving the extract after alcohol consumption.
本研究旨在评估[植物名称]叶提取物在实验动物中的解酒和保肝活性。进行了两项实验，分别在给予大鼠40%乙醇（5 g/kg体重）前30分钟或后30分钟给予单剂量的[植物名称]叶提取物（1、10或100 mg/kg体重）。在给予受试物质前后测量大鼠的运动活性。采集血样以测定乙醇、乙酸盐和肝酶水平。收集肝组织以评估酒精代谢酶、抗氧化酶活性和抗氧化剂水平。在乙醇给药前给大鼠服用[植物名称]叶提取物可增加运动活性并降低血乙醇水平。该提取物还可防止肝酶水平变化，并通过清除乙醇诱导的氧化应激产生的自由基表现出抗氧化活性。相反，在接受乙醇后给大鼠服用[植物名称]叶提取物能够将升高的肝酶水平降低至正常水平，并且可能通过刺激抗氧化酶的合成和/或活性来帮助抑制自由基的有害作用。在乙醇暴露前或后给予[植物名称]叶提取物均能够降低一种酒精代谢酶的活性以及降低血乙酸盐水平。总之，在饮酒前服用[植物名称]叶提取物可能有助于减轻宿醉症状，并且显示出比饮酒后服用提取物具有更好的保肝作用。
